Protean Regulation of Leukocyte Function by Nuclear Lamins

The leukocyte nucleus must be sufficiently elastic to squeeze through tissue barriers during migration, but not so collapsible as to risk damaging chromatin. The proper balance is struck in part by the composition of the nuclear lamina, a flexible meshwork composed mainly of intermediate filaments woven from type A and type B lamin proteins, that is located subjacent to the inner nuclear membrane. There is now increasing evidence that, in addition to influencing nuclear shape and stiffness and cell migration, lamins and lamin-interacting proteins may also interact functionally with chromatin to influence leukocyte gene expression, differentiation, and effector function, including T cell differentiation, B cell somatic hypermutation, and the formation of neutrophil extracellular traps (NETosis).

Automated summary

The leukocyte nucleus needs to be elastic enough for migration, but not collapsible to damage chromatin. The composition of the nuclear lamina plays a crucial role in maintaining this balance and influencing leukocyte gene expression and differentiation.