Nuclear Periphery and Telomere Maintenance: TERRA Joins the Stage

Long noncoding (lnc)RNAs derived from telomeres, the ends of linear eukaryotic chromosomes, help to maintain telomere length and stability by multiple means, including regulation of telomerase activity and recombination-based telomere maintenance. New findings in yeast promote a model in which telomere attachment to the nuclear envelope regulates telomere transcription and maintenance.

Automated summary

Long noncoding RNAs derived from telomeres help to maintain telomere length and stability through various mechanisms, such as regulating telomerase activity and recombination-based telomere maintenance. New findings in yeast propose a model where telomere attachment to the nuclear envelope regulates telomere transcription and maintenance.