☆ 4.2 Review

COVID-19 convalescent plasma: Interim recommendations from the AABB

TRANSFUSION (2021)

Related references

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Article Pathology

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG

Eric Salazar et al.

Summary: Convalescent plasma therapy containing high-titer anti-spike protein RBD IgG has shown to significantly reduce mortality in hospitalized COVID-19 patients when transfused within 44 hours, confirming previous findings and showing promise in the treatment of the disease.

AMERICAN JOURNAL OF PATHOLOGY (2021)

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Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

R. Libster et al.

Summary: A randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against SARS-CoV-2 in older adult patients within 72 hours after the onset of mild Covid-19 symptoms found that early administration of high-titer convalescent plasma reduced the progression of Covid-19 in mildly ill infected older adults.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Medicine, General & Internal

(A Little) Clarity on Convalescent Plasma for Covid-19

Louis M. Katz

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19

M. J. Joyner et al.

Summary: This study found that higher anti-SARS-CoV-2 IgG antibody levels in convalescent plasma were associated with a lower risk of death among patients hospitalized with Covid-19 who were not receiving mechanical ventilation. The association between antibody levels and mortality risk was moderated by mechanical ventilation status, with no significant effect seen in patients who had already received ventilation.

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A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

V. A. Simonovich et al.

Summary: There were no significant differences observed in clinical status or overall mortality between patients treated with convalescent plasma and those who received placebo in the treatment of severe Covid-19 pneumonia. The study results indicate that both groups had similar clinical outcomes and mortality rates after 30 days.

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Review Infectious Diseases

SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis

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Summary: This study aimed to characterize the viral load dynamics, duration of viral shedding, and viable virus shedding of SARS-CoV-2 in various body fluids. The findings suggest that while SARS-CoV-2 RNA shedding can be prolonged in respiratory and stool samples, the duration of viable virus shedding is relatively short-lived.

LANCET MICROBE (2021)

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Comparative Performance of Five Commercially Available Serologic Assays To Detect Antibodies to SARS-CoV-2 and Identify Individuals with High Neutralizing Titers

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Summary: Accurate serological assays are crucial for detecting SARS-CoV-2 antibodies, but commercial EIAs may not always accurately detect high nAb titers in individuals, indicating the limitations of current diagnostic methods for COVID-19 convalescent plasma donation.

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The epidemiology of platelet transfusions: an analysis of platelet use at 12 US hospitals

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Evan M. Bloch et al.

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Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19 A Randomized Clinical Trial

Ling Li et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Early safety indicators of COVID-19 convalescent plasma in 5000 patients

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Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients

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Sean T. H. Liu et al.

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Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)

Anup Agarwal et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Efficacy and safety of transfusing plasma from COVID-19 survivors to COVID-19 victims with severe illness. A double-blinded controlled preliminary study

Ossama Hamdy Salman et al.

EGYPTIAN JOURNAL OF ANAESTHESIA (2020)

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Michael P. Busch et al.

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Ruchika Goel et al.

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