Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 136, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2021.116182
Keywords
Covalent organic frameworks; Sample preparation; Proteomics; Endogenous substances; Biological analysis
Categories
Funding
- National Natural Science Foundation of China [22076222, 21904146]
- Natural Science Foundation of Guangdong Province [2020A1515010825, 2019A1515011722]
- projects of China Postdoctoral Science Foundation [2020M672973, 2019M653138]
- Fundamental Research Funds for the Central Universities [19lgpy125]
- postdoctoral Innovative Talents Support Program (Boxin Plan) [BX20190390]
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Covalent organic frameworks (COFs) are crystalline porous organic polymers constructed with molecular building units via diverse linkage chemistries, showing great potential in sample preparation science and biological analysis due to their tunable properties, large surface area, and unique structural robustness. However, current challenges and future trends need to be addressed in the preparation and applications of COFs in the biological field.
Covalent organic frameworks (COFs) are crystalline porous organic polymers constructed with molecular building units via diverse linkage chemistries. Recently, COF materials have shown great potential in sample preparation science due to their tunable properties, large surface area, and unique structural robustness. Here, a comprehensive overview is provided, consisting of a brief introduction on synthetic strategies of COFs for sample preparation and the progress in the application of COF materials as promising sorbents. Then, recent advancements of COFs in biological analysis including peptidomics and proteomics analysis, nucleic acids and endogenous substances analysis, enantiomers and pharmaceutical analysis are summarized and highlighted. Finally, the current challenges and future trends of COFs with respect to their preparation and applications in biological field are tentatively discussed. (C) 2021 Elsevier B.V. All rights reserved.
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