Research progress on the protection and detoxification of phytochemicals against aflatoxin B1-Induced liver toxicity

Aflatoxin B-1 (AFB(1)) is a potent hepatotoxic toxin, which can cause hepatitis, cirrhosis, and liver immunological damage. It has been involved in the etiology of human hepatocellular carcinoma. AFB(1) can cause oxidative stress in the body's metabolism process, and then cause cytotoxicity, such as apoptosis and DNA damage. Scientific research has discovered that phytochemicals can induce the detoxification pathway of AFB(1) through its biotransformation, thereby reducing the damage of AFB(1) to the human body. In clinical treatment, certain phytochemicals have been effectively used in the treatment of liver injury due to the advantages of multiple targets, multiple pathways, low toxicity and side effects. Therefore, the article summarizes the toxic mechanism of AFB(1)-induced hepatoxicity, and the related research progress of phytochemicals for preventing and treating its cytotoxicity and genotoxicity. We also look forward to the existing problems and application prospects of phytochemicals in the pharmaceutical industry, in order to provide theoretical reference for the prevention and treatment of AFB(1) poisoning in future research work.

Automated summary

Aflatoxin B-1 is a potent hepatotoxic toxin that can cause various liver diseases, but phytochemicals have been found to reduce its harmful effects and have shown positive results in clinical treatment. Researchers are looking into the potential of phytochemicals in the pharmaceutical industry for the prevention and treatment of AFB-1 poisoning.