Journal
TETRAHEDRON LETTERS
Volume 67, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2021.152864
Keywords
Photo-catalysis; Difluoromethylation; Activated alkene; Hypervalent iodine(III) reagent
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Funding
- National Natural Science Foundation of China [22077095]
- Natural Science Foundation of Tianjin City, China [18JCQNJC76600]
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This study reports the visible light-induced radical aryldifluoromethylation of N-arylacrylamides using [bis(difluoroacetoxy)iodo]benzene as a difluoromethylation reagent for the first time. The use of inexpensive and readily accessible reagents and mild reaction conditions make this method an alternative and practical strategy for the synthesis of difluoromethyl substituted oxindoles.
Visible light-induced radical aryldifluoromethylation of N-arylacrylamides using [bis(difluoroacetoxy)iodo]benzene as a difluoromethylation reagent is reported for the first time. The inexpensive and readily accessible reagents and the mild reaction conditions render this method an alternative and practical strategy for the synthesis of difluoromethyl substituted oxindoles. (C) 2021 Elsevier Ltd. All rights reserved.
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