Journal
TETRAHEDRON LETTERS
Volume 67, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2021.152894
Keywords
Griseofamine A; Total synthesis; Natural product
Categories
Funding
- National Natural Science Foundation of China [81903522]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-3-009]
- Drug Innovation Major Project [2018ZX09711-001-005-014, 2018ZX09711-001-005]
- non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2018PT35002]
- Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation
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This improved approach for synthesizing griseofamine A from L-4-bromo tryptophan methyl ester in 5 steps with a yield of 28% is more efficient, convenient, and scalable.
An improved approach for the synthesis of griseofamine A starting from L-4-bromo tryptophan methyl ester over 5 steps in 28% yield is described. This new synthetic strategy is more efficient, convenient and scalable. (C) 2021 Elsevier Ltd. All rights reserved.
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