Ir-catalyzed asymmetric hydrogenation of 3-arylindenones for the synthesis of chiral 3-arylindanones

An efficient synthesis of chiral 3-arylindanones via iridium-catalyzed asymmetric hydrogenation of 3-arylindenones has been developed. The reaction showed good compatibility with various functional groups, delivering a variety of 3-arylindanones in excellent yields and with good enantioselectivities. The reaction was also carried out on a gram-scale, delivering the product in quantitative yield. In addition, the products can be easily derivatized and transformed into natural products and pharmaceutical agents. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

An efficient synthesis of chiral 3-arylindanones was achieved through iridium-catalyzed asymmetric hydrogenation, showing good compatibility with various functional groups and delivering high yields with good enantioselectivities. The reaction was performed on a gram-scale with quantitative yield and the products were easily derivatized into natural products and pharmaceutical agents.