Journal
TALANTA
Volume 223, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2020.121768
Keywords
HOCl; Fluorescence probe; Near-infrared; Stokes shift; Imaging
Categories
Funding
- National Natural Science Foundation of China [21672080]
- Science and technology research project of Hubei Education Department [B2019063]
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CDCI-HClO is a novel reaction-based fluorescence probe that can rapidly, selectively, and sensitively detect hypochlorous acid, with a detection limit of about 4 nM. With a large Stokes shift of 190 nm, this probe was successfully applied to imaging hypochlorous acid in live cell, zebrafish, and living mice.
With a hybrid coumarin-dicyanoisophorone as report unit and dimethylthiocarbamate as response site, a novel reaction-based fluorescence probe (CDCI-HClO) was synthesized herein for rapid detection of hypochlorous acid (HOCl). CDCI-HClO can respond to HOCl quickly (almost in seconds), selectively, and sensitively, and give an obviously enhanced signal of near-infrared fluorescence at 700 nm. The detection limit of CDCI-HClO for HOCl is about 4 nM. Moreover, with the merit of a large Stokes shift (190 nm), CDCI-HClO was successfully applied to the imaging of HOCl in live cell, zebrafish, and living mice. All results demonstrated that CDCI-HClO is a valuable new NIR fluorescence imaging tool to detect hypochlorous acid in living systems.
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