Journal
SYNTHESIS-STUTTGART
Volume 53, Issue 12, Pages 2092-2102Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1706684
Keywords
cotylenin A; cotylenol; carbocycles; polycycles; natural products; ring-closing metathesis
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Funding
- Japan Society for the Promotion of Science (JSPS KAKENHI) [JP16K08180, JP18K14876, JP19K06981]
- Nagai Memorial Research Scholarship from the Pharmaceutical Society of Japan
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This paper describes the synthesis of the carbon skeleton of cotylenin A aglycone, achieved through key reactions including intramolecular aldol reaction, aldol coupling reaction, and ring-closing meta-thetasis. The stereochemistry was confirmed through single-crystal X-ray crystallographic analyses of related compounds.
In this paper, the synthesis of the carbon skeleton of cotylenin A aglycone is described. The key reactions, including an intramolecular aldol reaction, an aldol coupling reaction, and a ring-closing meta-thesis, allow for the effective and stereoselective access to the carbon skeleton of cotylenin A aglycone. The stereochemistry was confirmed by single-crystal X-ray crystallographic analyses of related compounds.
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