4.6 Article

Impact of individualized management of breakthrough cancer pain on quality of life in advanced cancer patients: CAVIDIOPAL study

Journal

SUPPORTIVE CARE IN CANCER
Volume 29, Issue 8, Pages 4799-4807

Publisher

SPRINGER
DOI: 10.1007/s00520-021-06006-1

Keywords

Breakthrough cancer pain; Quality of life; Transmucosal fentanyl; Individualized therapy; Palliative care

Funding

  1. Angelini Pharma Espana S.L.U.

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Individualized management of breakthrough cancer pain (BTcP) can improve quality of life (QoL) for patients with advanced cancer, with transmucosal fentanyl at low doses being the most common drug used.
Purpose The main aim of the study was to assess the impact of individualized management of breakthrough cancer pain (BTcP) on quality of life (QoL) of patients with advanced cancer in clinical practice. Methods A prospective, observational, multicenter study was conducted in patients with advanced cancer that were assisted by palliative care units. QoL was assessed with the EORTC QLQ-C30 questionnaire at baseline (V0) and after 28 days (V28) of individualized BTcP therapy. Data on background pain, BTcP, comorbidities, and frailty were also recorded. Results Ninety-three patients completed the study. Intensity, duration, and number of BTcP episodes were reduced (p < 0.001) at V28 with individualized therapy. Transmucosal fentanyl was used in 93.8% of patients, mainly by sublingual route. Fentanyl titration was initiated at low doses (78.3% of patients received doses of 67 mu g, 100 mu g, or 133 mu g) according to physician evaluation. At V28, mean perception of global health status had increased from 31.1 to 53.1 (p < 0.001). All scales of EORTC QLQ-C30 significantly improved (p < 0.001) except physical functioning, diarrhea, and financial difficulties. Pain scale improved from 73.6 +/- 22.6 to 35.7 +/- 22.3 (p < 0.001). Moreover, 85.9% of patients reported pain improvement. Probability of no >= 25% improvement in QoL was significantly higher in patients >= 65 years old (OR 1.39; 95% CI 1.001-1.079) and patients hospitalized at baseline (OR 4.126; 95% CI 1.227-13.873). Conclusion Individualized BTcP therapy improved QoL of patients with advanced cancer. Transmucosal fentanyl at low doses was the most used drug.

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