Journal
SUPPORTIVE CARE IN CANCER
Volume 29, Issue 8, Pages 4223-4238Publisher
SPRINGER
DOI: 10.1007/s00520-021-06042-x
Keywords
Chemotherapy-induced peripheral neuropathy; Cancer; Neuropathic Pain; Capsaicin
Funding
- Grunenthal
- Grunenthal GmbH
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Cancer diagnosis and treatment are significant events with potential severe side effects, including chemotherapy-induced peripheral neuropathy (CIPN). Some patients may face chronic symptoms, highlighting the importance of prevention and treatment strategies. Improved survival rates for cancer patients may lead to an increased incidence of CIPN in the future.
Cancer diagnosis and treatment are drastic events for patients and their families. Besides psychological aspects of the disease, patients are often affected by severe side effects related to the cancer itself or as a result of therapeutic interventions. Particularly, chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of oral or intravenous chemotherapy. The disorder may require dose reduction of chemotherapy and is accompanied by multiple symptoms with long-term functional impairment affecting quality of life (QoL), e.g., sensory and functional deteriorations as well as severe pain. Although CIPN may reverse or improve after termination of the causative chemotherapy, approximately 30-40% of patients are faced with chronicity of the symptoms. Due to the advantages in cancer diagnosis and treatments, survival rates of cancer patients rise and CIPN may occur even more frequently in the future. In this review, we summarize current recommendations of leading national and international societies regarding prevention and treatment options in CIPN. A special focus will be placed on current evidence for topical treatment of CIPN with high-dose capsaicin. Finally, an algorithm for CIPN treatment in clinical practice is provided, including both pharmacologic and non-pharmacologic modalities based on the clinical presentation.
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