Journal
SMALL
Volume 17, Issue 22, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202005449
Keywords
carbazoles; crystalline materials; orthotopic lung tumor; phosphorescence imaging; room temperature phosphorescence
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Funding
- NSFC [51961160730, 51873092]
- National Key R&D Program of China (Intergovernmental Cooperation Project) [2017YFE0132200]
- Fundamental Research Funds for the Central Universities, Nankai University
- Tianjin Science Fund for Distinguished Young Scholars [19JCJQJC61200]
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The study develops keto derivatives with efficient room temperature phosphorescence (RTP) through the regulation of molecular aggregation states by simple alkyl groups, demonstrating impressive luminescence performance suitable for various fields. Successful orthotopic lung tumor imaging with high signal-to-background ratio showcases the promise of pure organic RTP materials for disease diagnosis.
Pure organic persistent room temperature phosphorescence (RTP) materials have attracted wide attention owing to their great potential in various applications, particularly in bioimaging. However, it is still a challenge to manufacture organic RTP materials possessing quite high efficiency and long lifetime, owing to the high requirements for triplet excitons. In this study, a series of keto derivatives with efficient RTP in crystals are developed through the regulation of molecular aggregation states by simple alkyl groups, resulting in impressive luminescence performance with a longer lifetime and higher efficiency of up to 868 ms and 51.59%, respectively. All the alkyl-substituted derivatives exhibit bright RTP intensities after heavy grinding with a pestle, indicating their robust RTP features, which are suitable for many fields. Encouraged by the excellent RTP performance of these luminogens in the crystalline state, successful orthotopic lung tumor imaging with a high signal-to-background ratio (SBR) of 65 is demonstrated in this study to provide the promise of pure organic RTP materials for disease diagnosis, which hold the advantages of low autofluorescence interference and high signal-to-background ratio.
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