Interaction between tetracycline and microorganisms during wastewater treatment: A review

Tetracycline (TC) is a commonly used human and veterinary antibiotic that is mostly discharged into wastewater in the form of the parent compounds. At present, wastewater treatment plants (WWTPs) use activated sludge processes that are not specifically designed to remove such pollutants. Considering the biological toxicity of TC in aquatic environment, the migration and fate of TC in the process of wastewater treatment deserve attention. This paper reviews the influence of TC on the functional bacteria in the sludge matrix and the development of tetracycline-resistant genes, and also discusses their adsorption removal rates, their adsorption kinetics and adsorption isotherm models, and infers their adsorption mechanism. In addition, the biodegradation of TC in the process of biological treatment is reviewed. Co-metabolism and the role of dominant bacteria in the degradation process are described, along with the formation of degradation byproducts and their toxicity. Furthermore, the current popular integrated coupling-system for TC degradation is also introduced. This paper systematically introduces the interaction between TC and activated sludge in WWTPs. The review concludes by providing directions to address research and knowledge gaps in TC removal from wastewater. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

Tetracycline (TC) is a commonly used antibiotic in human and veterinary medicine, which is discharged into wastewater as parent compounds. The activated sludge processes in wastewater treatment plants are not effective in removing TC, and the impact of TC in wastewater treatment processes and removal methods should be emphasized.