Journal
SCIENCE
Volume 371, Issue 6530, Pages 690-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abd0951
Keywords
-
Categories
Funding
- NIH [R21DK114652, R21AG053592]
- Novo Nordisk Foundation [NNF-202585]
- NIDDK [F32DK121425]
Ask authors/readers for more resources
Circadian clocks coordinate physiology by molecular oscillators within cells, forming a system in complex organisms. Misalignment of clocks can disrupt coordination and is linked to various diseases.
Circadian clocks temporally coordinate physiology and align it with geophysical time, which enables diverse life-forms to anticipate daily environmental cycles. In complex organisms, clock function originates from the molecular oscillator within each cell and builds upward anatomically into an organism-wide system. Recent advances have transformed our understanding of how clocks are connected to achieve coherence across tissues. Circadian misalignment, often imposed in modern society, disrupts coordination among clocks and has been linked to diseases ranging from metabolic syndrome to cancer. Thus, uncovering the physiological circuits whereby biological clocks achieve coherence will inform on both challenges and opportunities in human health.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available