Journal
SCIENCE
Volume 371, Issue 6531, Pages 800-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abd6179
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Funding
- Office of Naval Research [N00014-14-1-0702, N00014-17-1-2610]
- NSF [1636364, 1317694]
- Air Force Office of Scientific Research [FA9550-16-1-0019]
- Natural Sciences and Engineering Research Council of Canada
- Banting Fellowship
- Orr Family Foundation
- Abedin Institute
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1636364] Funding Source: National Science Foundation
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DNA origami is a modular platform that combines molecular and colloidal components to create optical, electronic, and biological devices. By utilizing a unique energy landscape property, these devices can be accurately aligned and oriented. The optimization of device performance through orientation was demonstrated, as well as large-scale integration of DNA origami technology.
DNA origami is a modular platform for the combination of molecular and colloidal components to create optical, electronic, and biological devices. Integration of such nanoscale devices with microfabricated connectors and circuits is challenging: Large numbers of freely diffusing devices must be fixed at desired locations with desired alignment. We present a DNA origami molecule whose energy landscape on lithographic binding sites has a unique maximum. This property enabled device alignment within 3.2 degrees on silica surfaces. Orientation was absolute (all degrees of freedom were specified) and arbitrary (the orientation of every molecule was independently specified). The use of orientation to optimize device performance was shown by aligning fluorescent emission dipoles within microfabricated optical cavities. Large-scale integration was demonstrated with an array of 3456 DNA origami with 12 distinct orientations that indicated the polarization of excitation light.
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