Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 285, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.resp.2020.103596
Keywords
Ultrasound; Rat; Diaphragm; Rectus abdominis
Categories
Funding
- Chancellerie des Universites de Paris (Legs Poix)
- Fondation de France
- INSERM
- Universite de Versailles Saint-Quentin-en-Yvelines
- Fondation Medisite
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Ultrasound imaging is an accurate and reproducible technique for assessing and monitoring diaphragm and rectus abdominis structure and function in rats. Measuring respiratory parameters provides normal eupneic values. Histological studies and plethysmography were used to validate the technique and assess the physiological implications.
Ultrasound imaging is a non-invasive technique to assess organ function. Its potential application in rodents to evaluate respiratory function remains poorly investigated. We aimed to assess and validate ultrasound technique in rats to analyze inspiratory and expiratory muscles. We measured respiratory parameters to provide normal eupneic values. Histological studies and plethysmography were used to validate the technique and assess the physiological implications. A linear relationship was observed between ultrasound and histological data for diaphragm and rectus abdominis (RA) measurement. The tidal volume was significantly correlated with the right + left RA area (r = 0.76, p < 0.001), and the rapid shallow breathing index was significantly and inversely correlated with the right + left RA area (r=-0.53, p < 0.05). In the supine position, the right and left diaphragm expiratory thickness were not associated with tidal volume obtained in the physiological position. Ultrasound imaging is highly accurate and reproducible to assess and follow up diaphragm and RA structure and function in rats.
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