Related references
Note: Only part of the references are listed.dbSAP: single amino-acid polymorphism database for protein variation detection
Ruifang Cao et al.
NUCLEIC ACIDS RESEARCH (2017)
Strategies and challenges for the next generation of antibody drug conjugates
Alain Beck et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)
Birgit Schoeberl et al.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS (2017)
Superoxide Ion: Generation and Chemical Implications
Maan Hayyan et al.
CHEMICAL REVIEWS (2016)
Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog
Oleg A. Volkov et al.
ELIFE (2016)
Dichloroacetate and Trichloroacetate Toxicity in AML12 Cells: Role of Oxidative Stress
Ezdihar Hassoun et al.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2015)
Drug Metabolism by the Host and Gut Microbiota: A Partnership or Rivalry?
Hollie I. Swanson
DRUG METABOLISM AND DISPOSITION (2015)
Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease
W. H. Wilson Tang et al.
CIRCULATION RESEARCH (2015)
Pharmacokinetics
Jianghong Fan et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Enantioselective metabolism of primaquine by human CYP2D6
Pius S. Fasinu et al.
MALARIA JOURNAL (2014)
The ensemble nature of allostery
Hesam N. Motlagh et al.
NATURE (2014)
EC-BLAST: a tool to automatically search and compare enzyme reactions
Syed Asad Rahman et al.
NATURE METHODS (2014)
Emerging Principles for the Therapeutic Exploitation of Glycosylation
Martin Dalziel et al.
SCIENCE (2014)
Recombinant protein expression in microbial systems
German L. Rosano et al.
FRONTIERS IN MICROBIOLOGY (2014)
Grapefruit-medication interactions: Forbidden fruit or avoidable consequences?
David G. Bailey et al.
CANADIAN MEDICAL ASSOCIATION JOURNAL (2013)
Role of oxidative stress in infectious diseases. A review
Miroslav Pohanka
FOLIA MICROBIOLOGICA (2013)
Maturing antibody-drug conjugate pipeline hits 30
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2013)
Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects
S. C. Sim et al.
PHARMACOGENOMICS JOURNAL (2013)
Medicinal chemistry approaches to avoid aldehyde oxidase metabolism
David C. Pryde et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
The role of aldehyde oxidase in drug metabolism
Enrico Garattini et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Insights on P-Glycoprotein's Efflux Mechanism Obtained by Molecular Dynamics Simulations
Ricardo J. Ferreira et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)
Drug-target interaction prediction by random walk on the heterogeneous network
Xing Chen et al.
MOLECULAR BIOSYSTEMS (2012)
Architectures, mechanisms and molecular evolution of natural product methyltransferases
David K. Liscombe et al.
NATURAL PRODUCT REPORTS (2012)
DRUG DISCOVERY Chemical beauty contest
Pau Leeson
NATURE (2012)
Regiospecific and Stereospecific Triangulation of the Structures of Metabolites Formed by Sequential Metabolism at Multiple Prochiral Centers
Robert J. Greene et al.
DRUG METABOLISM AND DISPOSITION (2012)
Approaches for Predicting Human Pharmacokinetics Using Interspecies Pharmacokinetic Scaling
Hee Eun Kang et al.
ARCHIVES OF PHARMACAL RESEARCH (2011)
Glutathione transferases: a structural perspective
Aaron Oakley
DRUG METABOLISM REVIEWS (2011)
Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control
Chitranshu Kumar et al.
EMBO JOURNAL (2011)
The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1
Stanley Mukanganyama et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2011)
Chemistry and biology of reactive oxygen species in signaling or stress responses
Bryan C. Dickinson et al.
NATURE CHEMICAL BIOLOGY (2011)
Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities
Curtis J. Omiecinski et al.
TOXICOLOGICAL SCIENCES (2011)
Regulation of cancer cell metabolism
Rob A. Cairns et al.
NATURE REVIEWS CANCER (2011)
Antibody-Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies
Laurent Ducry et al.
BIOCONJUGATE CHEMISTRY (2010)
Insights on membrane topology and structure/function of UDP-glucuronosyltransferases
Jacques Magdalou et al.
DRUG METABOLISM REVIEWS (2010)
Heterogeneous distribution of SNPs in the human genome: Microsatellites as predictors of nucleotide diversity and divergence
Miguel A. Varela et al.
GENOMICS (2010)
Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery
David C. Pryde et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Evaluation of the impact of functional diversification on Poaceae, Brassicaceae, Fabaceae, and Pinaceae alcohol dehydrogenase enzymes
Claudia E. Thompson et al.
JOURNAL OF MOLECULAR MODELING (2010)
Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics
Jonathan Rittle et al.
SCIENCE (2010)
Health Consequences of Catabolic Synthesis of Hippuric Acid in Humans
Ronald W. Pero
CURRENT CLINICAL PHARMACOLOGY (2010)
A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype
Igor B. Kuznetsov et al.
BIOINFORMATICS (2009)
Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT Pie
Zoe Riches et al.
DRUG METABOLISM AND DISPOSITION (2009)
Counteracting myths about immigration and health
The Lancet
LANCET (2009)
Pharmacogenomics of adverse drug reactions: practical applications and perspectives
Laurent Becquemont
PHARMACOGENOMICS (2009)
Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation
Ana M. Gomes et al.
PHARMACOGENOMICS (2009)
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Stephen G. Aller et al.
SCIENCE (2009)
PXR and CAR in energy metabolism
Taira Wada et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2009)
A New Classification of Prodrugs: Regulatory Perspectives
Kuei-Meng Wu
PHARMACEUTICALS (2009)
Stress-response hormesis and aging: That which Does Not Kill Us Makes Us Stronger
David Gems et al.
CELL METABOLISM (2008)
In Vitro Cytochrome P450 Inhibition and Induction
Robert L. Walsky et al.
CURRENT DRUG METABOLISM (2008)
Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
Shu-Feng Zhou
CURRENT DRUG METABOLISM (2008)
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
Satori A. Marchitti et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
Natural selection has driven population differentiation in modern humans
Luis B. Barreiro et al.
NATURE GENETICS (2008)
Flexibility in the ABC transporter MsbA: Alternating access with a twist
Andrew Ward et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor
Krisztina Kohalmy et al.
DRUG METABOLISM AND DISPOSITION (2007)
Regulatory perspectives of Type II prodrug development and time-dependent toxicity management: Nonclinical Pharm/Tox analysis and the role of comparative toxicology
Kuei-Meng Wu et al.
TOXICOLOGY (2007)
A silent polymorphism in the MDR1 gene changes substrate specificity
Chava Kimchi-Sarfaty et al.
SCIENCE (2007)
Catechol-O-methyltransferase and its inhibitors in Parkinson's disease
Maria Joao Bonifacio et al.
CNS DRUG REVIEWS (2007)
Free radicals and antioxidants in normal physiological functions and human disease
Marian Valko et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Drug metabolism and pharmacogenetics: the British contribution to fields of international significance
J Caldwell
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Aerobic fate of the C-3′-thymidinyl radical in single-stranded DNA
Georges A. Lahoud et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2006)
International Union of Pharmacology. LXIII. Retinoid X receptors
Pierre Germain et al.
PHARMACOLOGICAL REVIEWS (2006)
Inter-organelle membrane contact sites: through a glass, darkly
Tim Levine et al.
CURRENT OPINION IN CELL BIOLOGY (2006)
Autoinduction of MKC-963 [(R)-1-(1-cyclohexylethylamino)-4-phenylphthalazine] metabolism in healthy volunteers and its retrospective evaluation using primary human hepatocytes and CDNA-expressed enzymes
Toshiyuki Shimizu et al.
DRUG METABOLISM AND DISPOSITION (2006)
The influence of various genotypes on the metabolic activity of NAT2 in a Chinese population
B Chen et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2006)
So many studies, too few subjects: Establishing functional relevance of genetic polymorphisms on pharmacokinetics
JA Williams et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2006)
Molecular physiology of renal organic anion transporters
T Sekine et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Pharmacogenetics, drug-metabolizing enzymes, and clinical practice
Sharon J. Gardiner et al.
PHARMACOLOGICAL REVIEWS (2006)
Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: Pitfalls, progress and promise
KA Bachmann
CURRENT DRUG METABOLISM (2006)
Phenotype-genotype analysis of CYP1A2 in Japanese patients receiving oral theophylline therapy
K Takata et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2006)
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2)
T Kubo et al.
DRUG METABOLISM AND DISPOSITION (2005)
Drug resistance in brain diseases and the role of drug efflux transporters
W Löscher et al.
NATURE REVIEWS NEUROSCIENCE (2005)
Improved early clinical development through human microdosing studies
IR Wilding et al.
DRUG DISCOVERY TODAY (2005)
Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism
SK Krueger et al.
PHARMACOLOGY & THERAPEUTICS (2005)
Induction of phase I, II and III drug metabolism/transport by xenobiotics
CJ Xu et al.
ARCHIVES OF PHARMACAL RESEARCH (2005)
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity
M Ingelman-Sundberg
PHARMACOGENOMICS JOURNAL (2005)
Effect of genetic polymorphisms in cytochrome P450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs - Clinical relevance
J Kirchheiner et al.
CLINICAL PHARMACOKINETICS (2005)
Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection
SK Balani et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2005)
Phase I and phase II drug metabolism: Terminology that we should phase out?
P Josephy et al.
DRUG METABOLISM REVIEWS (2005)
Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future
M Ingelman-Sundberg
TRENDS IN PHARMACOLOGICAL SCIENCES (2004)
A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily
RL Blanchard et al.
PHARMACOGENETICS (2004)
Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression
D Gardner-Stephen et al.
DRUG METABOLISM AND DISPOSITION (2004)
Principles of mononucleating and binucleating ligand design
AL Gavrilova et al.
CHEMICAL REVIEWS (2004)
Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene
MH Wu et al.
PHARMACOGENETICS (2004)
Monoamine oxidases: Certainties and uncertainties
KF Tipton et al.
CURRENT MEDICINAL CHEMISTRY (2004)
Sulfotransferase structural biology and inhibitor discovery
VL Rath et al.
DRUG DISCOVERY TODAY (2004)
Diversity of structures and properties among catalases
P Chelikani et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2004)
The role of glutathione in cancer
GK Balendiran et al.
CELL BIOCHEMISTRY AND FUNCTION (2004)
The blood-brain barrier: an overview - Structure, regulation, and clinical implications
P Ballabh et al.
NEUROBIOLOGY OF DISEASE (2004)
Design and synthesis of α-aryloxy-α-methylhydrocinnamic acids:: A novel class of dual peroxisome proliferator-activated receptor α/γ agonists
YP Xu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
A human drug metabolism database: Potential roles in the quantitative predictions of drug metabolism and metabolism-related drug-drug interactions
PW Erhardt
CURRENT DRUG METABOLISM (2003)
Dioxygenase enzymes: catalytic mechanisms and chemical models
TDH Bugg
TETRAHEDRON (2003)
Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
JK Nicholson et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans
PB Danielson
CURRENT DRUG METABOLISM (2002)
Kinetics and chemical equilibrium of the hydration of formaldehyde
JGM Winkelman et al.
CHEMICAL ENGINEERING SCIENCE (2002)
The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism
SA Kliewer et al.
ENDOCRINE REVIEWS (2002)
Structure and function of xanthine oxidoreductase: Where are we now?
R Harrison
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Serotonin N-acetyltransferase:: Mechanism and inhibition
WP Zheng et al.
CURRENT MEDICINAL CHEMISTRY (2002)
Medicinal chemistry in the new millennium. A glance into the future
PW Erhardt
PURE AND APPLIED CHEMISTRY (2002)
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein
S Ekins et al.
MOLECULAR PHARMACOLOGY (2002)
Metabonomics: a platform for studying drug toxicity and gene function
JK Nicholson et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
The use of in vitro methods to predict in vivo pharmacokinetics and drug interactions
KA Bachmann et al.
CURRENT DRUG METABOLISM (2001)
Structure and function of sulfotransferases
M Negishi et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)
Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of the PBRU
J Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
R Sachidanandam et al.
NATURE (2001)
Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1
JH de León et al.
MOLECULAR PHARMACOLOGY (2000)
Drug-like properties and the causes of poor solubility and poor permeability
CA Lipinski
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2000)
Pharmacogenetics and the practice of medicine
AD Roses
NATURE (2000)
Epoxide hydrolase - polymorphism and role in toxicology
CJ Omiecinski et al.
TOXICOLOGY LETTERS (2000)
Active and inhibited human catalase structures: Ligand and NADPH binding and catalytic mechanism
CD Putnam et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)
Mammalian microsomal cytochrome P450 monooxygenase: Structural adaptations for membrane binding and functional diversity
PA Williams et al.
MOLECULAR CELL (2000)