Journal
PURE AND APPLIED CHEMISTRY
Volume 93, Issue 3, Pages 273-403Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/pac-2018-0208
Keywords
absorption; bioanalytical methods; biodegradation; drug delivery; drug design; drug discovery; environmental chemistry; enzyme chemistry; medicinal chemistry; metabolism; oxidation; pharmaceuticals
Categories
Funding
- IUPAC Chemistry and Human Health Division (VII)
- Subcommittee on Drug Discovery and Development
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This project, started over 15 years ago, aimed to create a glossary of drug metabolism terms specifically for medicinal chemists. Through extensive beta-testing, it engaged international audiences and expanded to enhance interdisciplinary communication. The current version maintains a chemical structure theme and tutorial comments to educate early stage researchers and investigators in today's collaborative drug discovery teams.
This project originated more than 15 years ago with the intent to produce a glossary of drug metabolism terms having definitions especially applicable for use by practicing medicinal chemists. A first-draft version underwent extensive beta-testing that, fortuitously, engaged international audiences in a wide range of disciplines involved in drug discovery and development. It became clear that the inclusion of information to enhance discussions among this mix of participants would be even more valuable. The present version retains a chemical structure theme while expanding tutorial comments that aim to bridge the various perspectives that may arise during interdisciplinary communications about a given term. This glossary is intended to be educational for early stage researchers, as well as useful for investigators at various levels who participate on today's highly multidisciplinary, collaborative small molecule drug discovery teams.
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