Journal
PSYCHONEUROENDOCRINOLOGY
Volume 124, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2020.105047
Keywords
Chronic stress; Microbiome; Gut-brain axis; Volatility; Corticosterone
Categories
Funding
- European Research Council [704995]
- Science Foundation Ireland (SFI) [SFI/12/RC/2273]
- Irish Health Research Board, the Dept. of Agriculture, Food and the Marine and Enterprise Ireland
- Mead Johnson
- Cremo
- Suntory Wellness
- Nutricia
- Wellness
- 4D Pharma
- MyNewGut [613979]
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The microbiome-gut-brain-axis is a complex phenomenon affected by stress, exhibiting volatility and influencing stress responses. The study found a significant correlation between volatility and stress response indicators, observed in different experimental groups and health volunteers, as well as demonstrating inter-species similarities on a functional level.
The microbiome-gut-brain-axis is a complex phenomenon spanning several dynamic systems in the body which can be parsed at a molecular, cellular, physiological and ecological level. A growing body of evidence indicates that this axis is particularly sensitive to the effects of stress and that it may be relevant to stress resilience and susceptibility. Although stress-induced changes in the composition of the microbiome have been reported, the degree of compositional change over time, which we define as volatility, has not been the subject of in-depth scrutiny. Using a chronic psychosocial stress paradigm in male mice, we report that the volatility of the microbiome significantly correlated with several readouts of the stress response, including behaviour and corticosterone response. We then validated these findings in a second independent group of stressed mice. Additionally, we assessed the relationship between volatility and stress parameters in a cohort of health volunteers who were undergoing academic exams and report similar observations. Finally, we found inter-species similarities in the microbiome stress response on a functional level. Our research highlights the effects of stress on the dynamic microbiome and underscores the informative value of volatility as a parameter that should be considered in all future analyses of the microbiome.
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