Preparation and Characterization of a Novel Magnetic Nano Catalyst for Synthesis and Antibacterial Activities of Novel Furan-2(5H)-Ones Derivatives

Sulfamic acid 2-Aminobenzothiazole-6-carboxylic acid functionalized Fe3O4 nanoparticles as a novel organic-inorganic hybrid heterogeneous catalyst were manufactured and characterized by FT-IR, XRD, TGA, SEM, TEM, and VSM techniques. The catalytic activity of the magnetic catalyst was investigated through the one-pot synthesis of novel 3,4,5-trisubstituted furan-2(5H)-ones derivatives from aryl aldehydes, 4-amino pyridine, and dimethyl acetylenedicarboxylate. The structure of all the new synthesized derivatives was determined by FT-IR, H-1-NMR, and C-13-NMR. The synthetic compounds exert moderate activity against both Gram-positive and Gram-negative bacteria and their effectiveness is higher against Bacillus subtilis. This green nano catalytic procedure has good reversibility and provides clean production in a short reaction time. These characters make the method practical and economical for researchers.

Automated summary

In this study, sulfamic acid 2-aminobenzothiazole-6-carboxylic acid functionalized Fe3O4 nanoparticles were used as a novel organic-inorganic hybrid heterogeneous catalyst to synthesize a series of compounds with moderate antibacterial activity. The green nano catalytic procedure demonstrated good reversibility and clean production, making it practical and economical for researchers.