β-Cyclodextrin: An Efficient Supramolecular Catalyst for the Synthesis of Pyranoquinolines Derivatives under Ultrasonic Irradiation in Water

A newer, convenient and efficient approach has been designed for the diverse synthesis of 2-amino-4H-pyranoquinolines and achieved by a one-pot three-component reaction of aromatic aldehydes with ethyl cyanoacetate/malononitrile and 8-hydroxyquinoline catalyzed by beta-cyclodextrin as a reusable supramolecular catalyst in an aqueous medium under ultrasound irradiation. Target products were synthesized in a tandem process, which meets their requirements of pharmaceutical chemistry.

Automated summary

An innovative method for the synthesis of 2-amino-4H-pyranoquinolines has been developed, utilizing beta-cyclodextrin as a reusable supramolecular catalyst in a one-pot three-component reaction catalyzed under ultrasound irradiation in an aqueous medium. The tandem process allows for efficient and convenient synthesis of target products meeting pharmaceutical chemistry requirements.