Journal
PHYTOCHEMISTRY LETTERS
Volume 41, Issue -, Pages 142-146Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2020.11.017
Keywords
Delphinium tatsienense; Ranunculaceae; Diterpenoid alkaloids; Anti-inflammatory
Categories
Funding
- National Natural Science Foundation of China [31860095]
- Guizhou Provincial Natural Science Foundation [QKHJC[2018] 1193, QKH-J [2020]1Y377]
- Zunyi Science and Technology Project [ZSKHHZZ(2020)85]
- Excellent Young Talents Fund Program of Zunyi Medical University [18zy-005]
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Three new diterpenoid alkaloids were isolated from the whole plants of Delphinium tatsienense Franch., a folk medicine in China for wind-toxin syndrome treatment. The structures of these alkaloids were determined through extensive spectroscopic analyses. Their potential anti-inflammatory effects were evaluated against NO production in LPS-stimulated RAW 264.7 macrophages.
Three new diterpenoid alkaloids (DAs), including two lycaconitine-type C-19-DAs tatsiedines A and B (1 and 2) and a vakognavine-type C-20-DA tatsiedine C (3), have been isolated from the whole plants of Delphinium tatsienense Franch. (Ranunculaceae), a folk medicine for the treatment of wind-toxin syndrome in China. Their structures were established on the basis of extensive spectroscopic analyses. The isolated compounds were evaluated for their potential anti-inflammatory effects against NO production using LPS-stimulated RAW 264.7 macrophages.
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