4.4 Article

Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients

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Summary: The TRPM4 channel plays a crucial role in the heart, participating in multiple physiological processes including cardiac conduction, hypertrophic adaptations, and potentially cardiac arrhythmias. Research has shown that TRPM4 is essential for survival and is required to activate the Akt and Calcineurin pathways, while also regulating transient calcium amplitudes that may lead to cellular arrhythmias. This channel has two functions: a role in adaptive hypertrophy, and an association with NCX that could trigger cellular arrhythmias.

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