Breakthrough Candidemia in Pediatric Patients With Cancer From a Brazilian Center

We analyzed 19 cases of breakthrough candidemia from a referral pediatric cancer center in Brazil. All patients had neutropenia and were under antifungal prophylactic regimens, mostly micafungin (68%). Most of the patients were treated with amphotericin B formulations and 30-day mortality was 21%. Candida parapsilosis was the main etiologic agent (63%), and horizontal transmission was not evidenced by microsatellite analysis.

Automated summary

In a study of 19 cases of breakthrough candidemia from a referral pediatric cancer center in Brazil, most patients were under micafungin prophylaxis and treated with amphotericin B formulations. The main etiologic agent was Candida parapsilosis, with no evidence of horizontal transmission found through microsatellite analysis. The 30-day mortality rate after treatment with amphotericin B formulations was 21%.