Journal
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/6627355
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Funding
- National Key R&D Program of China [2018YFC1604405]
- China Central PublicInterest Scientific Institution Basal Research Fund [Y2020XK05]
- Key Project of Guangdong Provincial Science and Technology Program [2014B020205002]
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Intake of fruits, vegetables, nuts, and cereals, which are rich in antioxidants, can reduce the risk of cardiovascular diseases. Experimental studies have shown that compounds like polyphenols and anthocyanins have beneficial effects on the cardiovascular system by improving blood pressure, lipid profile, and reducing inflammation. Clinical trials have confirmed the cardiovascular-protective effect of some antioxidant natural products.
Cardiovascular diseases (CVDs) have gained increasing attention because of their high prevalence and mortality worldwide. Epidemiological studies revealed that intake of fruits, vegetables, nuts, and cereals could reduce the risk of CVDs, and their antioxidants are considered as the main contributors. Moreover, experimental studies showed that some antioxidant natural products and their bioactive compounds exerted beneficial effects on the cardiovascular system, such as polyphenols, polysaccharides, anthocyanins, epigallocatechin gallate, quercetin, rutin, and puerarin. The mechanisms of action mainly included reducing blood pressure, improving lipid profile, ameliorating oxidative stress, mitigating inflammation, and regulating gut microbiota. Furthermore, clinical trials confirmed the cardiovascular-protective effect of some antioxidant natural products, such as soursop, beetroot, garlic, almond, and green tea. In this review, we summarized the effects of some antioxidant natural products and their bioactive compounds on CVDs based on the epidemiological, experimental, and clinical studies, with special attention paid to the relevant mechanisms and clinical trials.
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