Journal
ORGANIC LETTERS
Volume 23, Issue 4, Pages 1194-1198Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04134
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Funding
- National Natural Science Foundation of China [81973166, 91753207, 81773568, 21702218]
- National Major Science and Technology Project Major New Drug Creation [2018ZX09711002-006001, 2018ZX09711002-008-005, 2018ZX09711002-004-012]
- Youth Innovation Promotion Association [2017333]
- Science and Technology Commission of Shanghai Municipality [18431907100]
- K. C. Wong Education Foundation
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A Rh(III)-catalyzed twofold unsymmetrical C-H alkenylation-annulation/thiolation reaction has been developed for the efficient synthesis of varied thiobenzofurans in a straightforward manner. This protocol demonstrates good functional group tolerance and broad substrate scope under mild reaction conditions.
A Rh(III)-catalyzed twofold unsymmetrical C-H alkenylation-annulation/thiolation reaction has been developed, enabling the straightforward and efficient synthesis of various thiobenzofurans in one step. This robust protocol proceeds with a broad substrate scope and good functional group tolerance under relatively mild reaction conditions.
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