4.8 Article

Rhodium-Catalyzed Twofold Unsymmetrical C-H Alkenylation-Annulation/Thiolation Reaction To Access Thiobenzofurans

Journal

ORGANIC LETTERS
Volume 23, Issue 4, Pages 1194-1198

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04134

Keywords

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Funding

  1. National Natural Science Foundation of China [81973166, 91753207, 81773568, 21702218]
  2. National Major Science and Technology Project Major New Drug Creation [2018ZX09711002-006001, 2018ZX09711002-008-005, 2018ZX09711002-004-012]
  3. Youth Innovation Promotion Association [2017333]
  4. Science and Technology Commission of Shanghai Municipality [18431907100]
  5. K. C. Wong Education Foundation

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A Rh(III)-catalyzed twofold unsymmetrical C-H alkenylation-annulation/thiolation reaction has been developed for the efficient synthesis of varied thiobenzofurans in a straightforward manner. This protocol demonstrates good functional group tolerance and broad substrate scope under mild reaction conditions.
A Rh(III)-catalyzed twofold unsymmetrical C-H alkenylation-annulation/thiolation reaction has been developed, enabling the straightforward and efficient synthesis of various thiobenzofurans in one step. This robust protocol proceeds with a broad substrate scope and good functional group tolerance under relatively mild reaction conditions.

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