Journal
ORGANIC LETTERS
Volume 23, Issue 4, Pages 1258-1262Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04241
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Funding
- NSFC [21702136, 21871117, 21502080, 21772071, 21772076, 91956203]
- '111' Program of MOE
- Major project of MOST [2018ZX09711001-005-002]
- STCSM [19JC1430100]
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A new and efficient method for the preparation of 2-aryl-2,3-dihydrobenzofuran scaffolds with excellent enantioselectivities and high yields has been developed through the Cu/SPDO-catalyzed [3 + 2] cycloaddition between quinone ester and styrene derivatives. Moreover, the asymmetric synthesis of natural corsifurans A and B from commercially available starting materials has been accomplished in two or three steps using this reaction as a key transformation.
A new, efficient approach toward the preparation of 2-aryl-2,3-dihydrobenzofuran scaffolds through the Cu/SPDO-catalyzed [3 + 2] cycloaddition between quinone ester and styrene derivatives has been developed. The procedure features excellent enantioselectivities (up to 99% ee), high yields (up to 96%), and broad substrate tolerance. Additionally, asymmetric synthesis of natural corsifurans A and B from commercially available starting materials has also been achieved in two or three steps using this reaction as a key transformation.
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