Journal
ORGANIC LETTERS
Volume 23, Issue 3, Pages 814-818Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04041
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Funding
- NSFC [21871031, 21702021, 22071011]
- Thousand Talents Program of Sichuan Province
- Chengdu Talents Program
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A Lewis acid-promoted [6+1] annulation reaction between sulfur ylides and modified vinyl benzoxazinanones was successfully achieved, providing a facile and practical approach for constructing a benzo[b]azepine skeleton. The key to success in this reaction lies in the installation of an electron-withdrawing group on the alkene moiety of the benzoxazinanones, expanding the scope of compatible substrates in the mild reaction system.
A Lewis acid-promoted [6+1] annulation between sulfur ylides and modified vinyl benzoxazinanones was described. In this reaction, the newly designed vinyl benzoxazinanones could serve as a novel six-atom synthon, and the key to success is the installation of an electron-withdrawing group on the alkene moiety of the benzoxazinanones. A broad range of substrates are compatible with this mild reaction system, thereby providing a facile and practical approach for constructing a benzo[b]azepine skeleton.
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