4.8 Article

Chemical Exchanges between Multilateral Symbionts

Journal

ORGANIC LETTERS
Volume 23, Issue 5, Pages 1648-1652

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00068

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Funding

  1. National Institutes of Health [U19 AI42720, U19 TW009872, R01 GM03496]
  2. Sao Paulo State Foundation (FAPESP) [2013/50954-0]
  3. American Lebenese Syrian Associated Charities

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This report presents the molecular exchange between multilateral symbiosis partners, resulting in the characterization of two new metabolites, which disrupt fatty acid biosynthesis by selectively inhibiting FabH.
Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.

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