Journal
ORGANIC LETTERS
Volume 23, Issue 5, Pages 1530-1534Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04056
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- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
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The synthesis of anilines and indoles from cyclohexanones using a Pd/C-ethylene system was successfully achieved under nonaerobic conditions with a simple combination of NH4OAc and K2CO3. The desired products were generated through hydrogen transfer between cyclohexanone and ethylene, with the reaction tolerating a variety of substitutions on the starting cyclohexanones.
The synthesis of anilines and indoles from cyclohexanones using a Pd/C-ethylene system is reported. A simple combination of NH4OAc and K2CO3 under nonaerobic conditions was found to be the most suitable to perform this reaction. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.
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