FCN1 polymorphisms are not the markers of dental caries susceptibility in Polish children: A case-control study

Objective To examine the association of four FCN1 SNPs: -542G>A (rs10120023), -144C>A (rs10117466), +6658C>T (rs148649884), and +7895A>G (rs150625869) with dental caries in Polish children. Subjects and Methods The study group consisted of 261 15-year-old Polish teenagers: 82 children with higher caries experience (having Decayed Missing Filled Teeth, DMFT >5) and 179 children with lower caries experience (having DMFT <= 5). Moreover, in additional comparison, a group of 229 children with caries experience (DMFT >= 1) was compared to a caries-free (DMFT =0) group of 32 children. Extraction of genomic DNA was performed from buccal swabs, and genotyping was performed by Real-Time PCR. Results FCN1 SNPs +6658C>T and +7895A>G appeared to be monomorphic in our sample. The genotype, allele, or haplotype distributions in FCN1 SNPs -542G>A and -144C>A in children with higher caries experience did not differ significantly from those in lower caries experience group. Similar results with no significant differences were demonstrated for subjects with DMFT >= 1 compared to subjects with DMFT =0. Conclusion FCN1 SNPs are not the markers of dental caries susceptibility in Polish children.

Automated summary

The study found that FCN1 SNPs are not associated with dental caries susceptibility in Polish children. There were no significant differences in the genotype, allele, or haplotype distributions of FCN1 SNPs between children with higher and lower caries experience.