Journal
NUCLEIC ACIDS RESEARCH
Volume 49, Issue 3, Pages 1724-1736Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkaa1259
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Funding
- Singapore National Research Foundation Investigatorship [NRF-NRFI2017-09]
- Singapore Ministry of Education Academic Research Fund Tier 2 [MOE2015-T21092]
- Nanyang Technological University (NTU Singapore)
- Nanyang Technological University
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This study investigates the adaptability of left-handed G4 structures towards the presence of bulges, presenting the structural characteristics of left-handed G4s accommodating varying numbers of bulges. Bulges in left-handed G4s exhibit distinct features compared to those in right-handed G4s, and elucidation of the intricate structural details may enhance understanding of the potential roles and limitations of these unique structures.
G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
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