Journal
NUCLEAR MEDICINE AND BIOLOGY
Volume 93, Issue -, Pages 22-36Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nucmedbio.2020.11.004
Keywords
BODIPY dyes; Molecular imaging; PET; Fluorescent; Radiofluorination
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2018R1D1A1 B07047572]
- National Research Foundation of Korea [NRF-2019R1A6A1A03031807]
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Dual positron emission tomography (PET)/optical imaging techniques have attracted scientific interest for clinical applications. The use of F-18-labelled BODIPY dyes has been proven to be practical as a hybrid PET/optical imaging probe.
Dual Positron emission tomography (PET)/optical imaging techniques have captured scientific interest for clinical applications due to their potential as an effective tool for visualizing in vivo information such as disease processes. 4,4'-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye has been considered an ideal platform strategy to achieve dual PET/optical imaging due to its photochemical nature and chemical structure. Various radiofluorination methods to prepare [F-18]BODIPY dye have been developed and established, ranging from nucle-ophilic substitution reactions to isotope exchange reactions. In addition, F-18-labelled BODIPY dyes for biologically important targets have been used for in vivo and ex vivo studies. These studies proved the practicality of [F-18] BODIPY dyes as a hybrid PET/optical imaging probe. In this review, recent advances in the synthesis and biological evaluation of F-18-labelled BODIPY dyes are described. (C) 2020 Elsevier Inc. All rights reserved.
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