4.6 Review

Hypoglossal Nerve Stimulation Therapy for the Treatment of Obstructive Sleep Apnea

Journal

NEUROTHERAPEUTICS
Volume 18, Issue 1, Pages 91-99

Publisher

SPRINGER
DOI: 10.1007/s13311-021-01012-x

Keywords

Hypoglossal nerve stimulation therapy; upper airway stimulation; surgery; obstructive sleep apnea; continuous positive airway pressure; continue positive airway pressure intolerance

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Hypoglossal nerve stimulation therapy is a treatment option for obstructive sleep apnea patients intolerant to CPAP therapy, which reduces respiratory parameters and improves subjective sleep complaints through direct neurostimulation of the hypoglossal nerve.
Hypoglossal nerve stimulation (HGNS) therapy was approved in 2014 for the treatment of obstructive sleep apnea in patients who are intolerant to continuous positive airway pressure (CPAP) therapy, which is reported in up to 40-60% of patients. This therapy works via direct neurostimulation of the hypoglossal nerve in synchrony with respiration, to open the airway via tongue stiffening and protrusion. Studies have demonstrated significant reductions in both respiratory parameters such as disordered breathing indices, as well as subjective sleep complaints, such as daytime sleepiness, with the use of this therapy. This has increased the repertoire of treatment options for sleep providers to recommend to those patients that are intolerant to CPAP therapy.

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