Journal
NEUROSCIENCE LETTERS
Volume 752, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2021.135825
Keywords
Morphine withdrawal; Minocycline; CaMKII; Ras; p-ERK; Midbrain periaqueductal gray
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Funding
- National Natural Science Foundation of China [81301145]
- Sichuan Research Center for Applied Psychology [CSXL-192A11]
- China College Students' Innovation and Entrepreneurship [S202013705032]
- Sichuan province College Students' Innovation and Entrepreneurship [S202013705077]
- Development and Regeneration Key Laboratory of Sichuan Province Chengdu Medical College [SYS20-10]
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Minocycline alleviates morphine withdrawal symptoms by inhibiting the activation of microglia and downregulating the expression of CaMKII, Ras, and p-ERK.
Objective: To investigate the effect of minocycline on morphine withdrawal symptoms. Methods: We established a rat model of morphine dependence, then injected the animals with naloxone to induce withdrawal symptoms. Minocycline was injected into the midbrain periaqueductal gray and its effect on withdrawal symptoms and Ca2+-dependent protein kinase (CaMKII), Ras, and phospho-extracellular signal-regulated kinase (p-ERK) expression was observed. Results: Minocycline inhibited withdrawal symptoms such as wet dog shakes, teeth chatter, and ptosis, perhaps by inhibiting the activation of microglia and the expression of CaMKII, Ras, and p-ERK. Minocycline had no effect on the behavior of control rats or on CaMKII, Ras, or p-ERK expression. Conclusion: Minocycline alleviates morphine withdrawal symptoms by inhibiting the activation of microglia and downregulating the expression of CaMKII, Ras, and p-ERK.
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