Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 121, Issue -, Pages 89-105Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2020.12.001
Keywords
Mice; Rats; Animal model; Ageing; Memory; Dietary supplements; Metabolism; Physiological stress; Locomotion; Healthy ageing
Categories
Funding
- Horizon 2020 Framework Programme
- H2020 AwE Ageing with Elegans'' [633589]
- Italian Ministry of Health
Ask authors/readers for more resources
The concept of healthspan focuses on increasing the number of years spent in good health rather than just extending lifespan. Natural compounds have shown promising effects on stress resistance and cognitive abilities in mouse and rat models of physiological ageing. Further studies are needed to delve deeper into the underlying mechanisms.
Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; healthspan is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available