Journal
NEURON
Volume 109, Issue 6, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2021.01.011
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Funding
- NIMH [R00MH118423, K99MH118423]
- NSF PIRE grant [1545858, U19 NS107616, U19 NS104590]
- NIH [MH 122391]
- Ministry of Science & ICT (MSIT), Republic of Korea [IBS-R026-D1-2021-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Office Of Internatl Science &Engineering
- Office Of The Director [1545858] Funding Source: National Science Foundation
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The study focuses on how incorporating synthetic hippocampal signals is constrained by preexisting circuit dynamics through optogenetic stimulation of CA1 neurons in mice. Stimulation induced persistent place field remapping and reflected circuit modification through altered spike transmission. The findings suggest that plasticity in recurrent/lateral inhibition may drive learning by rapidly associating existing states.
Memory models often emphasize the need to encode novel patterns of neural activity imposed by sensory drive. Prior learning and innate architecture likely restrict neural plasticity, however. Here, we test how the incorporation of synthetic hippocampal signals is constrained by preexisting circuit dynamics. We optogenetically stimulated small groups of CA1 neurons as mice traversed a chosen segment of a linear track, mimicking the emergence of place fields. Stimulation induced persistent place field remapping in stimulated and non-stimulated neurons. The emergence of place fields could be predicted from sporadic firing in the new place field location and the temporal relationship to peer neurons before the optogenetic perturbation. Circuit modification was reflected by altered spike transmission between connected pyramidal cells and inhibitory interneurons, which persisted during post-experience sleep. We hypothesize that optogenetic perturbation unmasked sub-threshold place fields. Plasticity in recurrent/lateral inhibition may drive learning through the rapid association of existing states.
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