Journal
NEUROMOLECULAR MEDICINE
Volume 23, Issue 4, Pages 561-571Publisher
HUMANA PRESS INC
DOI: 10.1007/s12017-021-08651-5
Keywords
COVID-19; Down syndrome; Immune dysregulation; SARS-CoV-2; Vaccine
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Funding
- Intramural Research Program of the National Institute on Aging
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Individuals with Down Syndrome (DS) are at higher risk of contracting COVID-19, especially those with Alzheimer's disease (AD). Urgent measures need to be taken to protect these patients, while global health systems should focus on interventions for prevention and control.
The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer's disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.
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