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Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice
Ana Maria Martin-Moreno et al.
JOURNAL OF NEUROINFLAMMATION (2012)
SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones
Gizem Donmez et al.
JOURNAL OF NEUROSCIENCE (2012)
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
Hyunkyung Jeong et al.
NATURE MEDICINE (2012)
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Iryna Benilova et al.
NATURE NEUROSCIENCE (2012)
Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease
Giuseppe Filomeni et al.
NEUROBIOLOGY OF AGING (2012)
Cell Surface Estrogen Receptor Alpha Is Upregulated during Subchronic Metabolic Stress and Inhibits Neuronal Cell Degeneration
Cristiana Barbati et al.
PLOS ONE (2012)
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
Benedetta Mannini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity
Shinji Tsutsumi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
John M. Ringman et al.
ALZHEIMERS RESEARCH & THERAPY (2012)
Confinement to Organelle-Associated Inclusion Structures Mediates Asymmetric Inheritance of Aggregated Protein in Budding Yeast
Rachel Spokoini et al.
CELL REPORTS (2012)
Unfolded Protein Responses With or Without Unfolded Proteins?
Erik Snapp
Cells (2012)
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins
Martin Gamerdinger et al.
EMBO REPORTS (2011)
Hydroxytyrosol reduces intracellular reactive oxygen species levels in vascular endothelial cells by upregulating catalase expression through the AMPK-FOXO3a pathway
Houda Zrelli et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Estrogen receptor mediates a distinct mitochondrial unfolded protein response
Luena Papa et al.
JOURNAL OF CELL SCIENCE (2011)
Gambogic Acid, a Natural Product Inhibitor of Hsp90
Jason Davenport et al.
JOURNAL OF NATURAL PRODUCTS (2011)
Identifying polyglutamine protein species in situ that best predict neurodegeneration
Jason Miller et al.
NATURE CHEMICAL BIOLOGY (2011)
Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson's Disease
Yuncheng Wu et al.
NEUROSIGNALS (2011)
Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice
Kathryn A. B. Simao da Silva et al.
PAIN (2011)
Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time
Eric A. Ariazi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission
Ines Moreno-Gonzalez et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2011)
The use of multi-target drugs in the treatment of neurodegenerative diseases
Cornelis J Van der Schyf
Expert Review of Clinical Pharmacology (2011)
Hsp70 and Its Molecular Role in Nervous System Diseases
Giuseppina Turturici et al.
BIOCHEMISTRY RESEARCH INTERNATIONAL (2011)
ANS Binding Reveals Common Features of Cytotoxic Amyloid Species
Benedetta Bolognesi et al.
ACS CHEMICAL BIOLOGY (2010)
Chaperone-assisted degradation: multiple paths to destruction
Nadja Kettern et al.
BIOLOGICAL CHEMISTRY (2010)
The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition
Chiara Giommarelli et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2010)
Roles of 17β-Estradiol Involve Regulation of Reelin Expression and Synaptogenesis in the Dentate Gyrus
Roland A. Bender et al.
CEREBRAL CORTEX (2010)
Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance
Verena Arndt et al.
CURRENT BIOLOGY (2010)
Leptin Reduces Infarct Size in Association with Enhanced Expression of CB2, TRPV1, SIRT-1 and Leptin Receptor
Yosefa Avraham et al.
CURRENT NEUROVASCULAR RESEARCH (2010)
Modulating expression of brain heat shock proteins by estrogen in ovariectomized mice model of aging
Yan Hou et al.
EXPERIMENTAL GERONTOLOGY (2010)
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
Shinji Kume et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
Daniel Paris et al.
JOURNAL OF NEUROINFLAMMATION (2010)
Heat shock protein 90 in neurodegenerative diseases
Wenjie Luo et al.
MOLECULAR NEURODEGENERATION (2010)
Cellular strategies for controlling protein aggregation
Jens Tyedmers et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
Mikko Taipale et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines
Glenda E. Gillies et al.
PHARMACOLOGICAL REVIEWS (2010)
Parkinson's disease: Exit toxins, enter genetics
Marie Westerlund et al.
PROGRESS IN NEUROBIOLOGY (2010)
Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
Evan T. Powers et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
(-)-Epigallocatechin-3-gallate Is a Novel Hsp90 Inhibitor
Zhengyu Yin et al.
BIOCHEMISTRY (2009)
Activation and clinical significance of the unfolded protein response in breast cancer
P. Scriven et al.
BRITISH JOURNAL OF CANCER (2009)
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
David A. Price et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2009)
Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
Lin Wang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
Inhibiting the transcription factor HSF1 as an anticancer strategy
Luke Whitesell et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2009)
Cannabinoid CB2 Receptor Agonists Protect the Striatum Against Malonate Toxicity: Relevance for Huntington's Disease
Onintza Sagredo et al.
GLIA (2009)
Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction
Tao Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide
Diego Albani et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease
Jennifer L. Wacker et al.
JOURNAL OF NEUROSCIENCE (2009)
Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival
Filippo Biamonte et al.
NEUROBIOLOGY OF DISEASE (2009)
Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
Sandy D. Westerheide et al.
SCIENCE (2009)
Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells
Vikas Sehdev et al.
JOURNAL OF ONCOLOGY (2009)
Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
Wenjie Luo et al.
BMC NEUROSCIENCE (2008)
Lighting Up the Stressed ER
Sang-Wook Kang et al.
CELL (2008)
The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
Konstanze F. Winklhofer et al.
EMBO JOURNAL (2008)
Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival and Longevity
Samson Mathews Samuel et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)
The CB2 cannabinoid receptor controls myeloid progenitor trafficking
Javier Palazuelos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Gedunin, a Novel Hsp90 inhibitor: Semisynthesis of Derivatives and Preliminary Structure-Activity Relationships
Gary E. L. Brandt et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
In Hye Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Adapting proteostasis for disease intervention
William E. Balch et al.
SCIENCE (2008)
Metabolic adaptations through the PGC-1α and SIRT1 pathways
Joseph T. Rodgers et al.
FEBS LETTERS (2008)
Derrubone, an inhibitor of the Hsp90 protein folding machinery
M. Kyle Hadden et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Human X-Box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines
Bianca P. Gomez et al.
FASEB JOURNAL (2007)
To be, or not to be -: molecular chaperones in protein degradation
V. Arndt et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
Emma L. Davenport et al.
BLOOD (2007)
Protective effects of icariin against learning and memory deficits induced by aluminium in rats
Yong Luo et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2007)
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
Tiago Fleming Outeiro et al.
SCIENCE (2007)
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies
Wenjie Luo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Sirt1 regulates aging and resistance to oxidative stress in the heart
Ralph R. Alcendor et al.
CIRCULATION RESEARCH (2007)
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
Chad A. Dickey et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Phytoestrogens activate estrogen receptor β1 and estrogenic responses in human breast and bone cancer cell lines
Brian G. Chrzan et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2007)
Cannabinoid CB2 receptor: a new target for controlling neural cell survival?
Javier Fernandez-Ruiz et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
Autophagy and neurodegeneration: when the cleaning crew goes on strike
Marta Martinez-Vicente et al.
LANCET NEUROLOGY (2007)
Potential medicinal plants for CNS disorders: an overview
Vikas Kumar
PHYTOTHERAPY RESEARCH (2006)
Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IκB kinase (IKK)
Guoliang Qing et al.
CELL RESEARCH (2006)
Apigenin suppresses cancer cell growth through ERβ
Paul Mak et al.
NEOPLASIA (2006)
Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein
Masahiro Waza et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2006)
Amyloid fibrils of mammalian prion protein are highly toxic to cultured cells and primary neurons
V Novitskaya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Cannabinoids and cancer: pros and cons of an antitumour strategy
Maurizio Bifulco et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Amyloids, prions and the inherent infectious nature of misfolded protein aggregates
C Soto et al.
TRENDS IN BIOCHEMICAL SCIENCES (2006)
Concise synthesis of pochonin A, an HSP90 inhibitor
E Moulin et al.
ORGANIC LETTERS (2005)
Resveratrol promotes clearance of Alzheimer's disease amyloid-β peptides
P Marambaud et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
M Waza et al.
NATURE MEDICINE (2005)
Some like it hot: the structure and function of small heat-shock proteins
M Haslbeck et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Inhibition of Hsp90 function delays and impairs recovery from heat shock
RF Duncan
FEBS JOURNAL (2005)
Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues
E Moulin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Prevention of Alzheimer's disease pathology by cannabinoids:: Neuroprotection mediated by blockade of microglial activation
BG Ramírez et al.
JOURNAL OF NEUROSCIENCE (2005)
Estrogen and regulation of heat shock protein expression in female cardiomyocytes:: cross-talk with NFκB signaling
KL Hamilton et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2004)
Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor α-dependent mechanism:: Relevance in cell proliferation
E Pozo-Guisado et al.
INTERNATIONAL JOURNAL OF CANCER (2004)
Mammalian SIRT1 represses forkhead transcription factors
MC Motta et al.
CELL (2004)
Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene:: EEIG1
DY Wang et al.
MOLECULAR ENDOCRINOLOGY (2004)
Targeting multiple signal transduction pathways through inhibition of Hsp90
H Zhang et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2004)
Oxysterol regulation of estrogen receptor α-mediated gene expression in a transcriptional activation assay system using HeLa cells
H Sato et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2004)
Celastrols as inducers of the heat shock response and cytoprotection
SD Westerheide et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition
K Patel et al.
CHEMISTRY & BIOLOGY (2004)
Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer
JA Mobley et al.
CARCINOGENESIS (2004)
Ginsenoside-Rb1 from Panax ginseng CA!Meyer activates estrogen receptor-α and -β, independent of ligand binding
JY Cho et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
F Yeung et al.
EMBO JOURNAL (2004)
Protein unfolding in the cell
S Prakash et al.
TRENDS IN BIOCHEMICAL SCIENCES (2004)
Interaction of reelin signaling and Lis1 in brain development
AH Assadi et al.
NATURE GENETICS (2003)
Inactivation of NF-κB by genistein is mediated via Akt signaling pathway in breast cancer cells
LJ Gong et al.
ONCOGENE (2003)
CHIP: a quality-control E3 ligase collaborating with molecular chaperones
S Murata et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2003)
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
R Kayed et al.
SCIENCE (2003)
Unfolding the role of protein misfolding in neurodegenerative diseases
C Soto
NATURE REVIEWS NEUROSCIENCE (2003)
Binding of ATP to heat shock protein 90 - Evidence for an ATP-binding site in the C-terminal domain
C Garnier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
M Bucciantini et al.
NATURE (2002)
A case-control study of dietary phytoestrogens and testicular cancer risk
FL Walcott et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2002)
Negative control of p53 by Sir2α promotes cell survival under stress
JY Luo et al.
CELL (2001)
hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase
H Vaziri et al.
CELL (2001)
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
A Sittler et al.
HUMAN MOLECULAR GENETICS (2001)
A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy
MG Glazier et al.
ARCHIVES OF INTERNAL MEDICINE (2001)
Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
MY Sherman et al.
NEURON (2001)
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone
MG Marcu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Phytosterols as anticancer dietary components: Evidence and mechanism of action
AB Awad et al.
JOURNAL OF NUTRITION (2000)
β-Amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis
T Harkany et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2000)
Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
PJ Muchowski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins
S Krobitsch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)