4.3 Article

Protein-based nanoformulations for α-tocopherol encapsulation

Journal

ENGINEERING IN LIFE SCIENCES
Volume 17, Issue 5, Pages 523-527

Publisher

WILEY
DOI: 10.1002/elsc.201600188

Keywords

alpha-Tocopherol; Anti-oxidant activity; Protein-based nanoparticles; Skin treatment; Ultrasounds

Funding

  1. Portuguese Foundation for Science and Technology (FCT) [UID/BIO/04469/2013]
  2. COMPETE [POCI-01-0145-FEDER-006684]
  3. BioTecNorte operation - European Regional Development Fund under the scope of Norte - Programa Operacional Regional do Norte [NORTE-01-0145-FEDER-000004]
  4. FCT [SFRH\BPD\98388\2013]

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Nanoparticles of BSA and silk fibroin (SF) with entrapped alpha-tocopherol were produced via ultrasonic emulsification.population with particle size of 200-300 nm and highly negatively charged were obtained for all the tested formulations. Entrapment efficiencies of around 99% revealed the effective encapsulation of alpha-tocopherol into the produced nanoformulations. Generally, these nanodevices did not induce significant cytotoxicity to human skin keratinocytes for all the concentrations tested. The developed formulations showed free radical scavenging of ABTS.(+) ability resulting from the synergistic effect between the proteins in formulation and the entrapped tocopherol. Overall, the results contribute for the establishment of BSA: VO and BSA: SF: VO as biodegradable and non-toxic nanoformulations for the functionalization of textile devices and controlled delivery of tocopherol into the skin.

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