The role of cap-dependent translation in aged-related changes in neuroimmunity and affective behaviors

Translation regulation in the context of aged-associated inflammation and behavioral impairments is not well characterized. Aged individuals experience lower life quality due to behavioral impairments. In this study, we used young and aged transgenic mice that are unable to activate the cap-binding protein, eukaryotic translation initiation factor 4E (eIF4E) to examine the role of protein translation control in aging, memory, depression, and anxiety. To determine how products of cap-dependent translation play a permissive role in aged-associated inflammation, we assessed levels of pro-inflammatory cytokines in various brain regions involved in the above-mentioned behaviors. We found that functional eIF4E is not necessary for age-related deficits in spatial and short-term memory but is important for depressive and anxiety-like behavior and this is correlated with pro-inflammatory cytokines in discrete brain regions. Thus, we have begun to elucidate a role for eIF4E phosphorylation in the context of aged-related behavioral impairments and chronic low-grade inflammation that may help identify novel immune modulators for therapeutic targets and decrease the burden of self-care among the geriatric population. (c) 2020 Elsevier Inc. All rights reserved.

Automated summary

This study investigated the role of protein translation control in aging-related memory, depression, and anxiety behaviors, finding that eIF4E is important for depressive and anxiety-like behaviors and correlates with pro-inflammatory cytokines in specific brain regions. This research may provide insights for identifying new immune modulators as therapeutic targets for geriatric population.