Related references
Note: Only part of the references are listed.Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70
Hyeon-Ju Jeong et al.
CELL DEATH AND DIFFERENTIATION (2020)
A randomized, double-blind, placebo-controlled phase 1b/2 study of ralimetinib, a p38 MAPK inhibitor, plus gemcitabine and carboplatin versus gemcitabine and carboplatin for women with recurrent platinum-sensitive ovarian cancer
Ignace Vergote et al.
GYNECOLOGIC ONCOLOGY (2020)
Requirement for epithelial p38α in KRAS-driven lung tumor progression
Jessica Vitos-Faleato et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
Dan He et al.
NATURE COMMUNICATIONS (2020)
A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia
Elena Arriazu et al.
BLOOD CANCER JOURNAL (2020)
p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells
Tsvetana Petrova et al.
SCIENTIFIC REPORTS (2020)
Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development
Benjamin P. Weaver et al.
DEVELOPMENTAL CELL (2020)
An updated patent review of p38 MAP kinase inhibitors (2014-2019)
Vanessa Haller et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2020)
Protective and Detrimental Roles of p38α Mitogen-Activated Protein Kinase in Different Stages of Nonalcoholic Fatty Liver Disease
Seonghwan Hwang et al.
HEPATOLOGY (2020)
Blockade of p38 kinase impedes the mobilization of protumorigenic myeloid populations to impact breast cancer metastasis
Justin Zonneville et al.
INTERNATIONAL JOURNAL OF CANCER (2020)
The p38 Pathway: From Biology to Cancer Therapy
Adrian Martinez-Limon et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation
Mei-Yin Liu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation
Yung-Hsuan Wu et al.
CELL DEATH & DISEASE (2020)
Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
Jia-Hua Hu et al.
NATURE COMMUNICATIONS (2020)
A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
Min Sung Gee et al.
ALZHEIMERS RESEARCH & THERAPY (2020)
P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b
Randa Naffa et al.
CELLS (2020)
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
Roel P. H. De Maeyer et al.
NATURE IMMUNOLOGY (2020)
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Helmut Sies et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
TGF-β Signaling
Kalliopi Tzavlaki et al.
BIOMOLECULES (2020)
Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies
Devikala Gurusamy et al.
CANCER CELL (2020)
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Mehdi Bouhaddou et al.
CELL (2020)
Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress
Moe Matsushita et al.
SCIENCE ADVANCES (2020)
Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α-TAB1 Complexes
Charlie Nichols et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation
Craig Donoghue et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation
Galia Maik-Rachline et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Functions of p38 MAP Kinases in the Central Nervous System
Prita R. Asih et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)
Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs
Jun Gui et al.
NATURE CANCER (2020)
Role of p38/MAPKs in Alzheimer's disease: implications for amyloid beta toxicity targeted therapy
Ghazaleh Kheiri et al.
REVIEWS IN THE NEUROSCIENCES (2019)
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis
Marion Curtis et al.
CELL METABOLISM (2019)
IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3
Pierre C. McCarthy et al.
IMMUNOLOGY AND CELL BIOLOGY (2019)
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer
Mohamed I. Saad et al.
EMBO MOLECULAR MEDICINE (2019)
BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma
Katharine Herbert et al.
GENES & DEVELOPMENT (2019)
G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2-and TAB1-TAB3-dependent pathway in endothelial cells
Neil J. Grimsey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Macrophage p38α promotes nutritional steatohepatitis through M1 polarization
Xiang Zhang et al.
JOURNAL OF HEPATOLOGY (2019)
P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress
Andrii Bugai et al.
MOLECULAR CELL (2019)
Autophagy-induced senescence is regulated by p38α signaling
Konstantin Slobodnyuk et al.
CELL DEATH & DISEASE (2019)
Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK
Caterina Carbonell et al.
CELL REPORTS (2019)
p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation That Is Required for GSK3β-βTrCP-Induced Snail Degradation
Ki-Jun Ryu et al.
CANCER RESEARCH (2019)
PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development
Kai Liu et al.
DEVELOPMENTAL CELL (2019)
IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
Carlota Colomer et al.
MOLECULAR CELL (2019)
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation
Jesse E. Jun et al.
SCIENCE SIGNALING (2019)
Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38α through TGF-β and JNK signaling
Raquel Batlle et al.
NATURE COMMUNICATIONS (2019)
Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
Jingyu Li et al.
NATURE COMMUNICATIONS (2019)
Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
Marta Navarrete et al.
NATURE COMMUNICATIONS (2019)
Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules
Alvaro Casadome-Perales et al.
NANOMEDICINE (2019)
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials
Ann Lin et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion
Sarah Geller et al.
CELL METABOLISM (2019)
Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program
Danielle Yi et al.
CELL REPORTS (2019)
p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma
Ling Yang et al.
FRONTIERS IN ONCOLOGY (2019)
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles
Angelica Ortiz et al.
CANCER CELL (2019)
TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy
Lingyun Xia et al.
CELL METABOLISM (2019)
MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer's disease models
Yehong Du et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)
The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells
Christiane Gopfert et al.
JOURNAL OF IMMUNOLOGY (2018)
Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
Begona Canovas et al.
CANCER CELL (2018)
Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
Haiquan Lu et al.
CANCER RESEARCH (2018)
Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis
Catrin Youssif et al.
EMBO MOLECULAR MEDICINE (2018)
Selective inhibition of the p38 alpha MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals
Chun Wang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation
Bennie Lemmens et al.
MOLECULAR CELL (2018)
MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer
Sylwia Gawrzak et al.
NATURE CELL BIOLOGY (2018)
Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome
Maria Letizia Giardino Torchia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis
Lucia Suarez-Lopez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Dynamic activation and regulation of the mitogen-activated protein kinase p38
Ganesan Senthil Kumar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer
Galia Maik-Rachline et al.
SCIENCE SIGNALING (2018)
Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition
Douglas S. Jones et al.
SCIENCE SIGNALING (2018)
Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells
Meghan S. Soustek et al.
CELL DEATH & DISEASE (2018)
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T alpha-synuclein model of Parkinson's disease
Jialong Chen et al.
CELL DEATH & DISEASE (2018)
Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS
Katherine L. Gibbs et al.
CELL DEATH & DISEASE (2018)
p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
Marina E. Borisova et al.
NATURE COMMUNICATIONS (2018)
p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
Talha Anwar et al.
NATURE COMMUNICATIONS (2018)
Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression
Kunpeng Liu et al.
CELL REPORTS (2018)
Metabolic benefits of inhibition of p38α in white adipose tissue in obesity
Shengjie Zhang et al.
PLOS BIOLOGY (2018)
p38α blocks brown adipose tissue thermogenesis through p38δ inhibition
Nuria Matesanz et al.
PLOS BIOLOGY (2018)
The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer
Galia Maik-Rachline et al.
SCIENCE SIGNALING (2018)
Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition
Douglas S. Jones et al.
SCIENCE SIGNALING (2018)
An exploratory clinical study of p38 kinase inhibition in Alzheimer's disease
Philip Scheltens et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2018)
Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
Bhavna Murali et al.
CANCER RESEARCH (2018)
P38 alpha/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
Ping Hu et al.
NATURE COMMUNICATIONS (2018)
Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death
Haruko Miura et al.
CELL REPORTS (2018)
The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration
Aurore L'honore et al.
ELIFE (2018)
Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis
Tingting Zheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse
Matthew J. Robson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential
Min-Kyung Choo et al.
SCIENCE SIGNALING (2018)
Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice
Jacob L. Brown et al.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2018)
The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules
Gian F. De Nicola et al.
JCI INSIGHT (2018)
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction
Morisada Hayakawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
Matthew A. Coelho et al.
IMMUNITY (2017)
Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity
Nirav G. Shah et al.
JOURNAL OF IMMUNOLOGY (2017)
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
Isabel Jaco et al.
MOLECULAR CELL (2017)
Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer's Disease
Jong Kil Lee et al.
MOLECULES (2017)
Interplay between metabolic identities in the intestinal crypt supports stem cell function
Maria J. Rodriguez-Colman et al.
NATURE (2017)
p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection
Manoj B. Menon et al.
NATURE CELL BIOLOGY (2017)
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Yves Dondelinger et al.
NATURE CELL BIOLOGY (2017)
Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation
Kimberly C. Lin et al.
NATURE CELL BIOLOGY (2017)
Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist
Erika Pellegrini et al.
STRUCTURE (2017)
p38γ and p38δ: From Spectators to Key Physiological Players
Ana Cuenda et al.
TRENDS IN BIOCHEMICAL SCIENCES (2017)
MKK6 controls T3-mediated browning of white adipose tissue
Nuria Matesanz et al.
NATURE COMMUNICATIONS (2017)
Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
Silvia Consalvi et al.
NATURE COMMUNICATIONS (2017)
Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy
Wenming Li et al.
NATURE COMMUNICATIONS (2017)
Dendritic cell MST1 inhibits Th17 differentiation
Chunxiao Li et al.
NATURE COMMUNICATIONS (2017)
Induction of oxidative metabolism by the p38α/MK2 pathway
Natalia Trempolec et al.
SCIENTIFIC REPORTS (2017)
miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice
Raymond Ng et al.
CELL REPORTS (2017)
Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations
Antonija Kuzmanic et al.
ELIFE (2017)
MMI-0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
Qinghang Meng et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)
Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis
Akshay Bhinge et al.
STEM CELL REPORTS (2017)
Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer's mouse model by controlling β-amyloid production
Sandra Colie et al.
SCIENTIFIC REPORTS (2017)
Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness
Hitoshi Takizawa et al.
CELL STEM CELL (2017)
Proteasome Activation by Small Molecules
Yves Leestemaker et al.
CELL CHEMICAL BIOLOGY (2017)
Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment
Kanstantsin V. Katlinski et al.
CANCER CELL (2017)
Pleiotropic properties of ASK1
Chihiro Sakauchi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)
Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans
Daniel C. Berry et al.
CELL METABOLISM (2017)
Targeting p38 MAP kinase signaling in cancer through post-translational modifications
Xiao Zou et al.
CANCER LETTERS (2017)
A First-in-Human Phase I Study of the Oral p38 MAPK Inhibitor, Ralimetinib (LY2228820 Dimesylate), in Patients with Advanced Cancer
Amita Patnaik et al.
CLINICAL CANCER RESEARCH (2016)
Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer
Valeria Santoro et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)
Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer
Valeria Santoro et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)
Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
Najoua Lalaoui et al.
CANCER CELL (2016)
ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Taru Muranen et al.
CANCER RESEARCH (2016)
Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells
Chun-Ting Cheng et al.
CANCER RESEARCH (2016)
Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions
A. Brichkina et al.
CELL DEATH AND DIFFERENTIATION (2016)
p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress
Daiki Karigane et al.
CELL STEM CELL (2016)
p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis
Anna Brichkina et al.
GENES & DEVELOPMENT (2016)
A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses
Eric H. Bent et al.
GENES & DEVELOPMENT (2016)
Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction A Randomized Clinical Trial
Michelle L. O'Donoghue et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)
The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells
Albert Gubern et al.
MOLECULAR CELL (2016)
Mechanism of early dissemination and metastasis in Her2+ mammary cancer
Kathryn L. Harper et al.
NATURE (2016)
Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia
Tomoya Fukawa et al.
NATURE MEDICINE (2016)
Cell Signaling and Stress Responses
Gokhan S. Hotamisligil et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)
Inactivation of nuclear GSK3 beta by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response
Tina M. Thornton et al.
NATURE COMMUNICATIONS (2016)
Mechanical cell competition kills cells via induction of lethal p53 levels
Laura Wagstaff et al.
NATURE COMMUNICATIONS (2016)
miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells
Mads Heilskov Rasmussen et al.
NATURE COMMUNICATIONS (2016)
Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity
Haiyoung Jung et al.
NATURE COMMUNICATIONS (2016)
Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
Wook-Bin Lee et al.
NATURE COMMUNICATIONS (2016)
CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
Xingxin Wu et al.
NATURE COMMUNICATIONS (2016)
ASK1 signalling regulates brown and beige adipocyte function
Kazuki Hattori et al.
NATURE COMMUNICATIONS (2016)
The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
Tania Quesada-Lopez et al.
NATURE COMMUNICATIONS (2016)
BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells
Xiaoyu Liu et al.
SCIENTIFIC REPORTS (2016)
MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration
Zhe Liu et al.
CELL REPORTS (2016)
Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling Pathway
Jessica Segales et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2
Kathleen M. S. E. Reyskens et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
p38 MAPK Signaling in Osteoblast Differentiation
Eddie Rodriguez-Carballo et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
p38MAPK and Chemotherapy: We Always Need to Hear Both Sides of the Story
Jesus Garcia-Cano et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
p38 gamma and p38 delta Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
Alejandra Escos et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer's Disease Mouse Models
Saktimayee M. Roy et al.
ACS CHEMICAL NEUROSCIENCE (2015)
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy
Ian G. Canne et al.
CANCER CELL (2015)
The Stress Kinase p38α as a Target for Cancer Therapy
Ana Igea et al.
CANCER RESEARCH (2015)
A Synergistic Interaction between Chk1-and MK2 Inhibitors in KRAS-Mutant Cancer
Felix Dietlein et al.
CELL (2015)
Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer
Jalaj Gupta et al.
FEBS JOURNAL (2015)
Molecular mechanisms linking amyloid β toxicity and Tau hyperphosphorylation in Alzheimer's disease
A. Lloret et al.
FREE RADICAL BIOLOGY AND MEDICINE (2015)
Stress kinases in the modulation of metabolism and energy balance
Elisa Manieri et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2015)
Stress Induces p38 MAPK-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival
Qian Yang et al.
MOLECULAR CELL (2015)
Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases
Andras Zeke et al.
MOLECULAR SYSTEMS BIOLOGY (2015)
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Nicolas Herranz et al.
NATURE CELL BIOLOGY (2015)
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression
Muhammad S. Alam et al.
NATURE MEDICINE (2015)
The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors
Jingjing Lin et al.
SCIENCE SIGNALING (2015)
The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1
Balamayooran Theivanthiran et al.
SCIENCE SIGNALING (2015)
MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia
Brian C. Evans et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS
S-H Chung et al.
CELL DEATH & DISEASE (2015)
Oscillation of p38 activity controls efficient pro-inflammatory gene expression
Taichiro Tomida et al.
NATURE COMMUNICATIONS (2015)
Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis
Melanie Tichet et al.
NATURE COMMUNICATIONS (2015)
The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation
Yongjie Wei et al.
ELIFE (2015)
The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors
Jingjing Lin et al.
SCIENCE SIGNALING (2015)
The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1
Balamayooran Theivanthiran et al.
SCIENCE SIGNALING (2015)
The case for inhibiting p38 mitogen-activated protein kinase in heart failure
Pelin Arabacilar et al.
FRONTIERS IN PHARMACOLOGY (2015)
PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer
Yanjie Zhang et al.
EBIOMEDICINE (2015)
p38 MAPK in cardioprotection - are we there yet?
E. D. Martin et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
Dual Function of p380α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival
Jalaj Gupta et al.
CANCER CELL (2014)
p38 MAPK: A Potential Target of Chronic Pain
X. Lin et al.
CURRENT MEDICINAL CHEMISTRY (2014)
F-Box Only Protein 31 (FBXO31) Negatively Regulates p38 Mitogen-activated Protein Kinase (MAPK) Signaling by Mediating Lysine 48-linked Ubiquitination and Degradation of Mitogen-activated Protein Kinase Kinase 6 (MKK6)
Jia Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Counter-regulation of T cell effector function by differentially activated p38
Muhammad S. Alam et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Beta-Like Importins Mediate the Nuclear Translocation of Mitogen-Activated Protein Kinases
Eldar Zehorai et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial
L. Kristin Newby et al.
LANCET (2014)
Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH
Jelena Urosevic et al.
NATURE CELL BIOLOGY (2014)
The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells
Alessio Lanna et al.
NATURE IMMUNOLOGY (2014)
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
Ramona Rudalska et al.
NATURE MEDICINE (2014)
Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions
Yuji Tokunaga et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
Xuefeng Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
TNF and MAP kinase signalling pathways
Guadalupe Sabio et al.
SEMINARS IN IMMUNOLOGY (2014)
p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Elise Alspach et al.
CANCER DISCOVERY (2014)
SnapShot: p38 MAPK Substrates
Natalia Trempolec et al.
CELL (2013)
Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK
Lorena Pereira et al.
EMBO MOLECULAR MEDICINE (2013)
Disruption of TAB1/p38α Interaction Using a Cell-permeable Peptide Limits Myocardial Ischemia/Reperfusion Injury
Qingyang Wang et al.
MOLECULAR THERAPY (2013)
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1
Gian Felice De Nicola et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial
William MacNee et al.
THORAX (2013)
The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1
Gopal P. Sapkota
OPEN BIOLOGY (2013)
Mitogen-activated protein kinases in innate immunity
J. Simon C. Arthur et al.
NATURE REVIEWS IMMUNOLOGY (2013)
The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation
Feride Oeztuerk-Winder et al.
BIOCHEMICAL JOURNAL (2012)
Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts
Dagmar Faust et al.
CELL COMMUNICATION AND SIGNALING (2012)
The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest
Alba Llopis et al.
CELL CYCLE (2012)
Gadd45γ and Map3k4 Interactions Regulate Mouse Testis Determination via p38 MAPK-Mediated Control of Sry Expression
Nick Warr et al.
DEVELOPMENTAL CELL (2012)
Ubiquitination-mediated regulation of interferon responses
Serge Y. Fuchs
GROWTH FACTORS (2012)
MAMMALIAN MAPK SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY STRESS AND INFLAMMATION: A 10-YEAR UPDATE
John M. Kyriakis et al.
PHYSIOLOGICAL REVIEWS (2012)
Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling
Nicholas Paquette et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
Adam Freund et al.
EMBO JOURNAL (2011)
A novel cardioprotective p38-MAPK/mTOR pathway
Gonzalo Hernandez et al.
EXPERIMENTAL CELL RESEARCH (2011)
Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor
Sabyasachi Bhattacharya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Acetylation of a Conserved Lysine Residue in the ATP Binding Pocket of p38 Augments Its Kinase Activity during Hypertrophy of Cardiomyocytes
Vinodkumar B. Pillai et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Genetic analysis of specific and redundant roles for p38α and p38β MAPKs during mouse development
Ivan del Barco Barrantes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Mechanisms and functions of p38 MAPK signalling
Ana Cuadrado et al.
BIOCHEMICAL JOURNAL (2010)
Mechanisms of mRNA translation of interferon stimulated genes
Sonali Joshi et al.
CYTOKINE (2010)
Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation
Christopher J. Staples et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
Matthew B. Greenblatt et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
A Role for p38 Stress-Activated Protein Kinase in Regulation of Cell Growth via TORC1
Megan Cully et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
p38 Mitogen-Activated Protein Kinase Promotes Cell Survival in Response to DNA Damage but Is Not Required for the G2 DNA Damage Checkpoint in Human Cancer Cells
Mark S. Phong et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding
Yarui Diao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Regulation of the immune response by stress-activated protein kinases
Mercedes Rincon et al.
IMMUNOLOGICAL REVIEWS (2009)
T Cell Receptor-mediated Activation of p38α by Mono-phosphorylation of the Activation Loop Results in Altered Substrate Specificity
Paul R. Mittelstadt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Targeting innate immunity protein kinase signalling in inflammation
Matthias Gaestel et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Signal integration by JNK and p38 MAPK pathways in cancer development
Erwin F. Wagner et al.
NATURE REVIEWS CANCER (2009)
The p38 MAPK stress pathway as a tumor suppressor or more?
Mathew Loesch et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
Macrophage deletion of p38α partially impairs lipopolysaccharide-induced cellular activation
Young Jun Kang et al.
JOURNAL OF IMMUNOLOGY (2008)
MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation - relevance in a mouse model of Parkinson's disease
Tobias Thomas et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation
Tina M. Thornton et al.
SCIENCE (2008)
P38 mitogen-activated protein kinase regulates myelination
Jeffery D. Haines et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2008)
P38α antagonizes p38γ activity through c-jun-dependent ubiquitin-proteasome pathways in regulating ras transformation and stress response
Xiaomei Qi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Regulation of MAPKs by growth factors and receptor tyrosine kinases
Menachem Katz et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
P38 MAP-Kinases pathway regulation, function and role in human diseases
Ana Cuenda et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway
Lijian Hui et al.
NATURE GENETICS (2007)
Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1 G93A-induced motor neuron death
Maarten Dewil et al.
NEUROBIOLOGY OF DISEASE (2007)
TAO kinases mediate activation of p38 in response to DNA damage
Malavika Raman et al.
EMBO JOURNAL (2007)
Manipulation of host signalling pathways by anthrax toxins
Benjamin E. Turk
BIOCHEMICAL JOURNAL (2007)
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors
June L. Round et al.
NATURE IMMUNOLOGY (2007)
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
H. Christian Reinhardt et al.
CANCER CELL (2007)
p38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis
Ignacio Dolado et al.
CANCER CELL (2007)
p38 alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
Juan Jose Ventura et al.
NATURE GENETICS (2007)
Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK
Sandra Peregrin et al.
CURRENT BIOLOGY (2006)
hnRNP A1 relocalization to the stress granules reflects a role in the stress response
Sonia Guil et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
The many paths to p38 mitogen-activated protein kinase activation in the immune system
Jonathan D. Ashwell
NATURE REVIEWS IMMUNOLOGY (2006)
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation
Sohini Mukherjee et al.
SCIENCE (2006)
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
K Ito et al.
NATURE MEDICINE (2006)
Generation and characterization of p38β (MAPK11) gene-targeted mice
VA Beardmore et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Phosphorylation of EEA1 by p38 MAP kinase regulates μ opioid receptor endocytosis
T Macé et al.
EMBO JOURNAL (2005)
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases
JM Salvador et al.
NATURE IMMUNOLOGY (2005)
The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway
JM Salvador et al.
NATURE IMMUNOLOGY (2005)
The role of MAPKs in adipocyte differentiation and obesity
F Bost et al.
BIOCHIMIE (2005)
Mechanical pressure-induced phosphorylation of p38 mitogen-activated protein kinase in epithelial cells via Src and protein kinase C
M Hofmann et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
WH Cao et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 Transgenic mice
C Bendotti et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)
p38 Kinase Is Activated in the Alzheimer's Disease Brain
Kenneth Hensley et al.
JOURNAL OF NEUROCHEMISTRY (2003)
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
K Godl et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Feedback control of the protein kinase TAK1 by SAPK2a/p38α
PCF Cheung et al.
EMBO JOURNAL (2003)
p38 MAP kinase is activated at early stages in Alzheimer's disease brain
AY Sun et al.
EXPERIMENTAL NEUROLOGY (2003)
Mechanism of p38 MAP kinase activation in vivo
D Brancho et al.
GENES & DEVELOPMENT (2003)
Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation - Evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia
M Tanno et al.
CIRCULATION RESEARCH (2003)
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
RM Biondi et al.
BIOCHEMICAL JOURNAL (2003)
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock
MT Uhlik et al.
NATURE CELL BIOLOGY (2003)
Negative feedback regulation of MKK6 mRNA stability by p38 alpha mitogen-activated protein kinase
C Ambrosino et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Ras and Rap control AMPA receptor trafficking during synaptic plasticity
JJ Zhu et al.
CELL (2002)
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity
DH Kim et al.
SCIENCE (2002)
Exip, a new alternative splicing variant of p38α, can induce an earlier onset of apoptosis in HeLa cells
T Sudo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α
BX Ge et al.
SCIENCE (2002)
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease
XW Zhu et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1
P Puigserver et al.
MOLECULAR CELL (2001)
Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength
G Alonso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses
VY Bolshakov et al.
NATURE NEUROSCIENCE (2000)
Essential role for p38α mitogen-activated protein kinase in placental angiogenesis
JS Mudgett et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38α and its splice isoform Mxi2
V Sanz et al.
FEBS LETTERS (2000)
Activation of the mitogen-activated protein kinase p38 by human cytomegalovirus infection through two distinct pathways: a novel mechanism for activation of p38
RA Johnson et al.
JOURNAL OF VIROLOGY (2000)
Share Paper
