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NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
Volume 18, Issue 5, Pages 291-292Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41575-021-00432-6
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NEC in preterm infants can lead to cognitive delay and neurodevelopmental disability, with CD4(+) T cells potentially playing a role in brain injury.
Necrotizing enterocolitis (NEC) is an acute intestinal emergency in preterm infants, which is often later complicated by cognitive delay and neurodevelopmental disability. A new study performed in mice suggests that CD4(+) T cells can travel from the NEC-inflamed gut to the brain and cause IFN gamma-mediated brain injury.
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