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LANCET NEUROLOGY (2012)
Neutralizing Antibodies Against AAV Serotypes 1, 2, 6, and 9 in Sera of Commonly Used Animal Models
Kleopatra Rapti et al.
MOLECULAR THERAPY (2012)
A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys
Sachiko Ohshima-Hosoyama et al.
PLOS ONE (2012)
Transduction of Neural Precursor Cells with TAT-Heat Shock Protein 70 Chaperone: Therapeutic Potential Against Ischemic Stroke after Intrastriatal and Systemic Transplantation
Thorsten R. Doeppner et al.
STEM CELLS (2012)
IMPROVED ANTI-TUMOR EFFECT OF LIPOSOMAL DOXORUBICIN AFTER TARGETED BLOOD-BRAIN BARRIER DISRUPTION BY MRI-GUIDED FOCUSED ULTRASOUND IN RAT GLIOMA
Lisa H. Treat et al.
ULTRASOUND IN MEDICINE AND BIOLOGY (2012)
Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons
Arpiar Saunders et al.
FRONTIERS IN NEURAL CIRCUITS (2012)
Engineering of Brome mosaic virus for biomedical applications
Ibrahim Yildiz et al.
RSC ADVANCES (2012)
Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles
Carlee E. Ashley et al.
ACS NANO (2011)
Gene Therapy for Pain: Results of a Phase I Clinical Trial
David J. Fink et al.
ANNALS OF NEUROLOGY (2011)
Phase IB Study of Gene-Mediated Cytotoxic Immunotherapy Adjuvant to Up-Front Surgery and Intensive Timing Radiation for Malignant Glioma
E. Antonio Chiocca et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
Yasuo Uchida et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Adenosine Receptor Signaling Modulates Permeability of the Blood-Brain Barrier
Aaron J. Carman et al.
JOURNAL OF NEUROSCIENCE (2011)
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial
Peter A. LeWitt et al.
LANCET NEUROLOGY (2011)
Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain
Xiaoying Zhuang et al.
MOLECULAR THERAPY (2011)
Systemic Gene Delivery in Large Species for Targeting Spinal Cord, Brain, and Peripheral Tissues for Pediatric Disorders
Adam K. Bevan et al.
MOLECULAR THERAPY (2011)
Several rAAV Vectors Efficiently Cross the Blood-brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System
Hongwei Zhang et al.
MOLECULAR THERAPY (2011)
Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model
Francesca Re et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Lydia Alvarez-Erviti et al.
NATURE BIOTECHNOLOGY (2011)
Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
Ruenn Chai Lai et al.
REGENERATIVE MEDICINE (2011)
Human brain endothelial cells are responsive to adenosine receptor activation
Jeffrey H. Mills et al.
PURINERGIC SIGNALLING (2011)
Illuminating viral infections in the nervous system
Dorian B. McGavern et al.
NATURE REVIEWS IMMUNOLOGY (2011)
Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease
Tomas Bjorklund et al.
BRAIN (2010)
Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer
Paul R. Lockman et al.
CLINICAL CANCER RESEARCH (2010)
Prevalence and stability of antibodies to the BK and JC polyomaviruses: a long-term longitudinal study of Australians
Annika Antonsson et al.
JOURNAL OF GENERAL VIROLOGY (2010)
A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease
Shin-ichi Muramatsu et al.
MOLECULAR THERAPY (2010)
A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins
Sara Salinas et al.
NATURE REVIEWS MICROBIOLOGY (2010)
Structure and function of the blood-brain barrier
N. Joan Abbott et al.
NEUROBIOLOGY OF DISEASE (2010)
Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe8ψ(CH2NH)Arg9]-BK in a F98 glioma rat model: An MRI study
Jerome Cote et al.
NEUROPEPTIDES (2010)
The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells
Richard Daneman et al.
PLOS ONE (2010)
Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors
F. Xu et al.
CANCER GENE THERAPY (2009)
Exosomes - vesicular carriers for intercellular communication
Mikael Simons et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors
A. A. Rahim et al.
GENE THERAPY (2009)
Caveolin-1 tumor-promoting role in human melanoma
Federica Felicetti et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
Detection of Intact rAAV Particles up to 6 Years After Successful Gene Transfer in the Retina of Dogs and Primates
Knut Stieger et al.
MOLECULAR THERAPY (2009)
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
Kevin D. Foust et al.
NATURE BIOTECHNOLOGY (2009)
Safety and tolerability of putaminal AADC gene therapy for Parkinson disease
C. W. Christine et al.
NEUROLOGY (2009)
A Clinical Trial of Gene Therapy for Chronic Pain
Darren Wolfe et al.
PAIN MEDICINE (2009)
Dopamine Gene Therapy for Parkinson's Disease in a Nonhuman Primate Without Associated Dyskinesia
Bechir Jarraya et al.
SCIENCE TRANSLATIONAL MEDICINE (2009)
CNS Delivery Via Adsorptive Transcytosis
Francoise Herve et al.
AAPS JOURNAL (2008)
Biochemical and spectroscopic studies of human melanotransferrin (MTf): Electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins
Sebastien Farnaud et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2
Michel Demeule et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
William J. Marks et al.
LANCET NEUROLOGY (2008)
Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
Shengming Dai et al.
MOLECULAR THERAPY (2008)
Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium
Nickolai Sheikov et al.
ULTRASOUND IN MEDICINE AND BIOLOGY (2008)
Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index
Nathan McDannold et al.
ULTRASOUND IN MEDICINE AND BIOLOGY (2008)
Identification and design of peptides as a new drug delivery system for the brain
Michel Demeule et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Transvascular delivery of small interfering RNA to the central nervous system
Priti Kumar et al.
NATURE (2007)
AAV2 - mediated delivery of human neurturin to the rat nigrostriatal system: Long-term efficacy and tolerability of CERE-120 for Parkinson's disease
Mehdi Gasmi et al.
NEUROBIOLOGY OF DISEASE (2007)
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial
Michael G. Kaplitt et al.
LANCET (2007)
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys
Jeffrey H. Kordower et al.
ANNALS OF NEUROLOGY (2006)
A dose-ranging study of AAV-hAADC therapy in parkinsonian monkeys
John R. Forsayeth et al.
MOLECULAR THERAPY (2006)
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption
Manabu Kinoshita et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound
M Kinoshita et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Adeno-associated virus serotypes: Vector toolkit for human gene therapy
Zhijian Wu et al.
MOLECULAR THERAPY (2006)
Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier
L Costantino et al.
JOURNAL OF CONTROLLED RELEASE (2005)
Adeno-associated virus (AAV)-7 and-8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation
L Denby et al.
GENE THERAPY (2005)
Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes:: results of thefirst phase I clinical trial
B Escudier et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2005)
A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
MA Morse et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2005)
An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells
I Sauer et al.
BIOCHEMISTRY (2005)
CD98hc (SLC3A2) mediates integrin signaling
CC Feral et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system
C Burger et al.
MOLECULAR THERAPY (2004)
Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles
N Sheikov et al.
ULTRASOUND IN MEDICINE AND BIOLOGY (2004)
Clades of Adeno-associated viruses are widely disseminated in human tissues
GP Gao et al.
JOURNAL OF VIROLOGY (2004)
Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells
SI Chisalita et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)
Adeno-associated viruses undergo substantial evolution in primates during natural infections
GP Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
High transcytosis of melanotransferrin (P97) across the blood brain barrier
M Demeule et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
GP Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Exosomes:: Composition, biogenesis and function
C Théry et al.
NATURE REVIEWS IMMUNOLOGY (2002)
Expression of a system L neutral amino acid transporter at the blood-brain barrier
H Matsuo et al.
NEUROREPORT (2000)
Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors
JM Alisky et al.
NEUROREPORT (2000)