Journal
NATURE NANOTECHNOLOGY
Volume 16, Issue 5, Pages 538-548Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41565-020-00843-7
Keywords
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Funding
- Shandong Provincial Key Research and Development Program (Major Scientific and Technological Innovation Project) [2019JZZY021013]
- Shandong Provincial Key Research and Development Program [2019GSF108080]
- Funds for Youth Interdisciplinary and Innovation Research Groups of Shandong University [2020QNQT003]
- National Natural Science Foundation of China [81874419]
- Major New Drug Creation Project of China [2017ZX09301064]
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The study introduces an injectable hydrogel system that stimulates tumoricidal immunity after GBM surgical resection, effectively reducing its recurrence. This system induces immunogenic cell death and sustained T-cell infiltration to attack residual tumor cells, significantly suppressing postoperative GBM recurrence.
Immunotherapies have revolutionized intervention strategies for many primary cancers, but have not improved the outcomes of glioblastoma multiforme (GBM), which remains one of the most lethal malignant cerebral tumours. Here we present an injectable hydrogel system that stimulates tumoricidal immunity after GBM surgical resection, which mitigates its relapse. The hydrogel comprises a tumour-homing immune nanoregulator, which induces immunogenic cell death and suppression of indoleamine 2,3-dioxygenase-1, and chemotactic CXC chemokine ligand 10, for a sustained T-cell infiltration. When delivered in the resected tumour cavity, the hydrogel system mimics a 'hot' tumour-immunity niche for attacking residual tumour cells and significantly suppresses postoperative GBM recurrence. Our work provides an alternative strategy for conferring effective tumoricidal immunity in GBM patients, which may have a broad impact in the immunotherapy of 'cold' tumours after surgical intervention.
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