Journal
NATURE IMMUNOLOGY
Volume 22, Issue 3, Pages 268-269Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41590-021-00874-9
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Brain tumors consume more oxygen, resulting in a hypoxic microenvironment that impairs innate gamma delta T cell-mediated antitumor activity. However, by reducing oxygen consumption in brain tumors or inhibiting hypoxia-inducible factor-1 alpha in gamma delta T cells, the tumor-killing activity of gamma delta T cells can be rejuvenated, leading to prolonged survival in mice with brain tumors.
Brain tumors respire more oxygen, causing a hypoxic microenvironment that impairs innate gamma delta T cell-mediated antitumor activity. Reducing oxygen consumption by brain tumors or inhibiting hypoxia-inducible factor-1 alpha in gamma delta T cells reinvigorates gamma delta T cell tumor-killing activity, leading to prolonged survival in brain-tumor-bearing mice.
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