Related references
Note: Only part of the references are listed.Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
Ryan J. Quinton et al.
NATURE (2021)
Context is everything: aneuploidy in cancer
Uri Ben-David et al.
NATURE REVIEWS GENETICS (2020)
Quantitative Proteomics of the Cancer Cell Line Encyclopedia
David P. Nusinow et al.
CELL (2020)
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
Steven M. Corsello et al.
NATURE CANCER (2020)
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
Edmond M. Chan et al.
NATURE (2019)
Next-generation characterization of the Cancer Cell Line Encyclopedia
Mahmoud Ghandi et al.
NATURE (2019)
ilastik: interactive machine learning for (bio) image analysis
Stuart Berg et al.
NATURE METHODS (2019)
Genomic and Functional Approaches to Understanding Cancer Aneuploidy
Alison M. Taylor et al.
CANCER CELL (2018)
Chromosomes trapped in micronuclei are liable to segregation errors
Mar Soto et al.
JOURNAL OF CELL SCIENCE (2018)
Genome doubling shapes the evolution and prognosis of advanced cancers
Craig M. Bielski et al.
NATURE GENETICS (2018)
Genetic and transcriptional evolution alters cancer cell line drug response
Uri Ben-David et al.
NATURE (2018)
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration
James M. McFarland et al.
NATURE COMMUNICATIONS (2018)
Patient-derived xenografts undergo mouse-specific tumor evolution
Uri Ben-David et al.
NATURE GENETICS (2017)
Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer
Jacqueline M. Mason et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells
Sunyoung Hwang et al.
CELL REPORTS (2017)
Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma
Floris Foijer et al.
ELIFE (2017)
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Aravind Subramanian et al.
CELL (2017)
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening
E. Robert McDonald et al.
CELL (2017)
Defining a Cancer Dependency Map
Aviad Tsherniak et al.
CELL (2017)
Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System
Stefano Santaguida et al.
DEVELOPMENTAL CELL (2017)
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
Matthew G. Rees et al.
NATURE CHEMICAL BIOLOGY (2016)
A Landscape of Pharmacogenomic Interactions in Cancer
Francesco Iorio et al.
CELL (2016)
Assessment of megabase-scale somatic copy number variation using single-cell sequencing
Kristin A. Knouse et al.
GENOME RESEARCH (2016)
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
Andrew J. Aguirre et al.
CANCER DISCOVERY (2016)
The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity
Thomas Wild et al.
CELL REPORTS (2016)
Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons
Hilda van den Bos et al.
GENOME BIOLOGY (2016)
Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells
Anastasia Y. Kuznetsova et al.
CELL CYCLE (2015)
Kif18a is specifically required for mitotic progression during germ line development
Anne Czechanski et al.
DEVELOPMENTAL BIOLOGY (2015)
An efficient and scalable analysis framework for variant extraction and refinement from population-scale DNA sequence data
Goo Jun et al.
GENOME RESEARCH (2015)
Targeting Mitosis in Cancer: Emerging Strategies
Carmen Dominguez-Brauer et al.
MOLECULAR CELL (2015)
Chromothripsis from DNA damage in micronuclei
Cheng-Zhong Zhang et al.
NATURE (2015)
limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie et al.
NUCLEIC ACIDS RESEARCH (2015)
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
Brinton Seashore-Ludlow et al.
CANCER DISCOVERY (2015)
Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A
Joachim Braun et al.
ACS CHEMICAL BIOLOGY (2015)
Unique features of the transcriptional response to model aneuploidy in human cells
Milena Duerrbaum et al.
BMC GENOMICS (2014)
Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress
Floris Foijer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Single cell sequencing reveals low levels of aneuploidy across mammalian tissues
Kristin A. Knouse et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis
Jason M. Sheltzer
CANCER RESEARCH (2013)
An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules
Amrita Basu et al.
CELL (2013)
Pan-cancer patterns of somatic copy number alteration
Travis I. Zack et al.
NATURE GENETICS (2013)
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
Wanjuan Yang et al.
NUCLEIC ACIDS RESEARCH (2013)
Aneuploidy causes proteotoxic stress in yeast
Ana B. Oromendia et al.
GENES & DEVELOPMENT (2012)
Systematic identification of genomic markers of drug sensitivity in cancer cells
Mathew J. Garnett et al.
NATURE (2012)
Absolute quantification of somatic DNA alterations in human cancer
Scott L. Carter et al.
NATURE BIOTECHNOLOGY (2012)
Fast gapped-read alignment with Bowtie 2
Ben Langmead et al.
NATURE METHODS (2012)
Molecular signatures database (MSigDB) 3.0
Arthur Liberzon et al.
BIOINFORMATICS (2011)
Kif18A Uses a Microtubule Binding Site in the Tail for Plus-End Localization and Spindle Length Regulation
Lesley N. Weaver et al.
CURRENT BIOLOGY (2011)
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation
Robin M. Ricke et al.
JOURNAL OF CELL BIOLOGY (2011)
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis
Kwanwoo Lee et al.
JOURNAL OF CELL BIOLOGY (2011)
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine
Stefano Santaguida et al.
JOURNAL OF CELL BIOLOGY (2010)
Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
Rocio Sotillo et al.
NATURE (2010)
Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity
Darren J. Baker et al.
CANCER CELL (2009)
Effects of aneuploidy on cellular physiology and cell division in haploid yeast
Eduardo M. Torres et al.
SCIENCE (2007)
DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists
Da Wei Huang et al.
NUCLEIC ACIDS RESEARCH (2007)
The spindle-assembly checkpoint in space and time
Andrea Musacchio et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression
Monika I. Mayr et al.
CURRENT BIOLOGY (2007)
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice
Rocio Sotillo et al.
CANCER CELL (2007)
Genome-wide genetic analysis of polyploidy in yeast
Zuzana Storchova et al.
NATURE (2006)
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
A Subramanian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint
GJPL Kops et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Phase I study of oral CI-994 in combination with carboplatin and paclitaxel in the treatment of patients with advanced solid tumors
LR Pauer et al.
CANCER INVESTIGATION (2004)
Share Paper
