Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 6, Pages 1522-1528Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1897591
Keywords
Xylaria nigripes; resorcinol; neuroprotective effects
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Funding
- National Natural Sciences Foundation of China [81903513, 31801789]
- China Postdoctoral Science Foundation [2020M682599]
- South-Central University for Nationalities
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Four new resorcinol derivatives were isolated from the solid fermentation of Xylaria nigripes, with their structures determined through spectroscopic analysis and calculations. Compound 1 is an optical mixture and exhibits neuroprotective effects against PC12 cell damage induced by OGD.
Four new resorcinol derivatives, namely (-)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (-)-1 by chiral HPLC. The neuroprotective effects of 1-3 against the damage of PC12 cells induced by oxygen and glucose deprivation (OGD) were evaluated.
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