Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes

Four new resorcinol derivatives, namely (-)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (-)-1 by chiral HPLC. The neuroprotective effects of 1-3 against the damage of PC12 cells induced by oxygen and glucose deprivation (OGD) were evaluated.

Automated summary

Four new resorcinol derivatives were isolated from the solid fermentation of Xylaria nigripes, with their structures determined through spectroscopic analysis and calculations. Compound 1 is an optical mixture and exhibits neuroprotective effects against PC12 cell damage induced by OGD.