Journal
NATURAL PRODUCT COMMUNICATIONS
Volume 16, Issue 2, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X21996153
Keywords
Chaenomeles sinensis (Thouin) Koehne; fruits; chemical constituents; terpenoids; protective effect on PC12 cells
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Funding
- National Key Research and Development Project [2017YFC1702800]
- Central Government Guide Local Science and Technology Development Funds [14104349]
- Key Scientific Research Project of Institutions of Higher Learning in Henan [21B360003]
- Special Project of Scientific Research on Traditional Chinese Medicine in Henan [20-21ZY2151]
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Two new compounds, chaenomelesterpenoid A and chaenomelesterpenoid B, isolated from Chaenomeles sinensis fruits, showed protective effects against corticosterone-induced damage in PC-12 cells, improving cell viability significantly.
A new sesquiterpenoid, chaenomelesterpenoid A (1), and a new norisoprenoid, chaenomelesterpenoid B (2), were isolated from the fruits of Chaenomeles sinensis (Thouin) Koehne. Their structures were determined by NMR spectroscopy and MS. In addition, the protective effects of the compounds were tested against corticosterone-induced damage in PC-12 cells using real-time cellular analysis (RTCA). Compounds 1 and 2 significantly improved cell viability and corticosterone-induced damage in PC-12 cells with EC50 values of 15.7 and 12.6 mu M, respectively.
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